iPTMnet Report for Q03060 (CREM)
Protein Information
| UniProt AC / UniProt ID | Q03060 / CREM_HUMAN |
| Protein Name | cAMP-responsive element modulator |
| Gene Name | Name: CREM |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q03060 |
| PRO Name | cAMP-responsive element modulator (human) |
| Definition | A cAMP-responsive element modulator that is encoded in the genome of human. |
| Short Label | hCREM |
| Category | organism-gene |
DAG ViewQ03060 (CREM) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S42 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S108 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S116 | Phosphorylation | score2 | phospho.ELM | 8404858 | ||
| S120 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y121 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S129 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| T148 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T259 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S271 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 18220336 | ||
| S274 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 18220336 | ||
| S277 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 18220336 | ||
| T286 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S47 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S50 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S53 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T62 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S35 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S38 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S41 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T50 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T33 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S36 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S36 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8404858 | |
| S45 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S53 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S57 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S66 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S67 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S80 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S196 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S199 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S202 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T211 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T63 | Phosphorylation | score1 | HPRD | 8404858 | ||
| T63 | Phosphorylation | P19784 (CSNK2A2) | score1 | HPRD | 8404858 | |
| T63 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 8404858 | |
| S66 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S66 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8404858 | |
| S75 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S83 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S83 | Phosphorylation | P49840 (GSK3A) | score1 | HPRD | 8404858 | |
| S83 | Phosphorylation | P49841 (GSK3B) | score1 | HPRD | 8404858 | |
| S87 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S87 | Phosphorylation | P06493 (CDK1) | score1 | HPRD | 8404858 | |
| S87 | Phosphorylation | P17252 (PRKCA) | score1 | HPRD | 8404858 | |
| S87 | Phosphorylation | P17612 (PRKACA) | score1 | HPRD | 8404858 | |
| S87 | Phosphorylation | Q13555 (CAMK2G) | score1 | HPRD | 8404858 | |
| S87 | Phosphorylation | Q13557 (CAMK2D) | score1 | HPRD | 8404858 | |
| S96 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S97 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S110 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S110 | Phosphorylation | P06493 (CDK1) | score1 | HPRD | 8404858 | |
| S110 | Phosphorylation | P19784 (CSNK2A2) | score1 | HPRD | 8404858 | |
| S110 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8404858 | |
| S110 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 8404858 | |
| S226 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S229 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S232 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T241 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S87 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S29 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S32 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S35 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T44 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S39 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S42 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S45 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T54 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T47 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S50 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S50 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8404858 | |
| S67 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S71 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S80 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S81 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S94 | Phosphorylation | score1 | HPRD | 8404858 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T63 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S66 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S66 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8404858 | |
| S75 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S83 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S87 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S96 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S97 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S110 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S175 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S178 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S181 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T190 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S39 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S42 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S45 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T54 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T47 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S50 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S50 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8404858 | |
| S59 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S67 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S71 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S80 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S81 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S94 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S147 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S150 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S153 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T162 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T63 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S66 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S66 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8404858 | |
| S75 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S83 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S87 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S96 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S97 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S110 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S226 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S229 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S232 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T241 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T63 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S66 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S66 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8404858 | |
| S75 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S83 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S87 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S96 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S97 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S110 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S163 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S166 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S169 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T178 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S136 | Phosphorylation | score2 | neXtProt | 8404858 | ||
| S136 | Phosphorylation | P06493 (CDK1) | score2 | neXtProt | 8404858 | |
| K316 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R321 | Methylation | score1 | PhosphoSitePlus | |||
| K330 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K337 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K340 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T8 | Phosphorylation | score1 | HPRD | 8404858 | ||
| S171 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S174 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S177 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T186 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T12 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S47 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S50 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S53 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| T62 | Phosphorylation | score0 | HPRD | 18669648 | ||
| K88 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R93 | Methylation | score1 | PhosphoSitePlus | |||
| K102 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K109 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K112 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S29 | L29 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S35 | L35 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S39 | L39 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S47 | L47 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| R93 | H93 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] | |
| S147 | L147 | Biomuta | DOID:1324 / lung cancer [ cosmic, cosmic ] | |
| S163 | L163 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S171 | L171 | Biomuta | DOID:1324 / lung cancer [ cosmic, cosmic ] | |
| S175 | L175 | Biomuta | DOID:1324 / lung cancer [ cosmic, cosmic ] | |
| S196 | L196 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S226 | L226 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S271 | L271 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
