Protein Information

Cytoscape View


UniProt AC / UniProt ID Q03060 / CREM_HUMAN
Protein Name cAMP-responsive element modulator
Gene Name Name: CREM
Organism Homo sapiens (Human)

PRO ID PR:Q03060
DAG View
PRO Name cAMP-responsive element modulator (human)
Definition A cAMP-responsive element modulator that is encoded in the genome of human.
Short Label hCREM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q03060 (CREM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S42 Phosphorylation HPRD 8404858
S108 Phosphorylation HPRD 18669648, 20068231
S116 Phosphorylation phospho.ELM 8404858
S120 Phosphorylation PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus   UniProt 23186163
T148 Phosphorylation HPRD 18669648
T259 Phosphorylation PhosphoSitePlus
S271 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S274 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S277 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
T286 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation HPRD 18669648, 20068231
S50 Phosphorylation HPRD 18669648
S53 Phosphorylation HPRD 18669648, 20068231
T62 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 18669648, 20068231
S38 Phosphorylation HPRD 18669648
S41 Phosphorylation HPRD 18669648, 20068231
T50 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T33 Phosphorylation HPRD 8404858
S36 Phosphorylation P48729 (CSNK1A1) HPRD 8404858
S45 Phosphorylation HPRD 8404858
S53 Phosphorylation HPRD 8404858
S57 Phosphorylation HPRD 8404858
S66 Phosphorylation HPRD 8404858
S67 Phosphorylation HPRD 8404858
S80 Phosphorylation HPRD 8404858
S196 Phosphorylation HPRD 18669648, 20068231
S199 Phosphorylation HPRD 18669648
S202 Phosphorylation HPRD 18669648, 20068231
T211 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T63 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD 8404858
S66 Phosphorylation P48729 (CSNK1A1) HPRD 8404858
S75 Phosphorylation HPRD 8404858
S83 Phosphorylation P49840 (GSK3A) , P49841 (GSK3B) HPRD 8404858
S87 Phosphorylation P06493 (CDK1) , Q13555 (CAMK2G) , P17252 (PRKCA) , Q13557 (CAMK2D) , P17612 (PRKACA) HPRD 8404858
S96 Phosphorylation HPRD 8404858
S97 Phosphorylation HPRD 8404858
S110 Phosphorylation P06493 (CDK1) , P48729 (CSNK1A1) , P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD 8404858
S226 Phosphorylation HPRD 18669648, 20068231
S229 Phosphorylation HPRD 18669648
S232 Phosphorylation HPRD 18669648, 20068231
T241 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S87 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation HPRD 18669648, 20068231
S32 Phosphorylation HPRD 18669648
S35 Phosphorylation HPRD 18669648, 20068231
T44 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation HPRD 18669648, 20068231
S42 Phosphorylation HPRD 18669648
S45 Phosphorylation HPRD 18669648, 20068231
T54 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T47 Phosphorylation HPRD 8404858
S50 Phosphorylation P48729 (CSNK1A1) HPRD 8404858
S67 Phosphorylation HPRD 8404858
S71 Phosphorylation HPRD 8404858
S80 Phosphorylation HPRD 8404858
S81 Phosphorylation HPRD 8404858
S94 Phosphorylation HPRD 8404858
Site PTM Type PTM Enzyme Score Source PMID
T63 Phosphorylation HPRD 8404858
S66 Phosphorylation P48729 (CSNK1A1) HPRD 8404858
S75 Phosphorylation HPRD 8404858
S83 Phosphorylation HPRD 8404858
S87 Phosphorylation HPRD 8404858
S96 Phosphorylation HPRD 8404858
S97 Phosphorylation HPRD 8404858
S110 Phosphorylation HPRD 8404858
S175 Phosphorylation HPRD 18669648, 20068231
S178 Phosphorylation HPRD 18669648
S181 Phosphorylation HPRD 18669648, 20068231
T190 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation HPRD 18669648, 20068231
S42 Phosphorylation HPRD 18669648
S45 Phosphorylation HPRD 18669648, 20068231
T54 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T47 Phosphorylation HPRD 8404858
S50 Phosphorylation P48729 (CSNK1A1) HPRD 8404858
S59 Phosphorylation HPRD 8404858
S67 Phosphorylation HPRD 8404858
S71 Phosphorylation HPRD 8404858
S80 Phosphorylation HPRD 8404858
S81 Phosphorylation HPRD 8404858
S94 Phosphorylation HPRD 8404858
S147 Phosphorylation HPRD 18669648, 20068231
S150 Phosphorylation HPRD 18669648
S153 Phosphorylation HPRD 18669648, 20068231
T162 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T63 Phosphorylation HPRD 8404858
S66 Phosphorylation P48729 (CSNK1A1) HPRD 8404858
S75 Phosphorylation HPRD 8404858
S83 Phosphorylation HPRD 8404858
S87 Phosphorylation HPRD 8404858
S96 Phosphorylation HPRD 8404858
S97 Phosphorylation HPRD 8404858
S110 Phosphorylation HPRD 8404858
S226 Phosphorylation HPRD 18669648, 20068231
S229 Phosphorylation HPRD 18669648
S232 Phosphorylation HPRD 18669648, 20068231
T241 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T63 Phosphorylation HPRD 8404858
S66 Phosphorylation P48729 (CSNK1A1) HPRD 8404858
S75 Phosphorylation HPRD 8404858
S83 Phosphorylation HPRD 8404858
S87 Phosphorylation HPRD 8404858
S96 Phosphorylation HPRD 8404858
S97 Phosphorylation HPRD 8404858
S110 Phosphorylation HPRD 8404858
S163 Phosphorylation HPRD 18669648, 20068231
S166 Phosphorylation HPRD 18669648
S169 Phosphorylation HPRD 18669648, 20068231
T178 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S136 Phosphorylation P06493 (CDK1) neXtProt 8404858
K316 Ubiquitination PhosphoSitePlus
R321 Methylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD 8404858
S171 Phosphorylation HPRD 18669648, 20068231
S174 Phosphorylation HPRD 18669648
S177 Phosphorylation HPRD 18669648, 20068231
T186 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T12 Phosphorylation PhosphoSitePlus
S47 Phosphorylation HPRD 18669648, 20068231
S50 Phosphorylation HPRD 18669648
S53 Phosphorylation HPRD 18669648, 20068231
T62 Phosphorylation HPRD 18669648
K88 Ubiquitination PhosphoSitePlus
R93 Methylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 18669648, 20068231
S38 Phosphorylation HPRD 18669648
S41 Phosphorylation HPRD 18669648, 20068231
T50 Phosphorylation HPRD 18669648