iPTMnet Report for Q02763 (TEK)
Protein Information
| UniProt AC / UniProt ID | Q02763 / TIE2_HUMAN |
| Protein Name | Angiopoietin-1 receptor precursor |
| Gene Name | Name: TEK Synonyms:TIE2,VMCM,VMCM1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q02763 |
| PRO Name | angiopoietin-1 receptor (human) |
| Definition | An angiopoietin-1 receptor that is encoded in the genome of human. |
| Short Label | hTEK |
| Category | organism-gene |
DAG ViewQ02763 (TEK) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T115 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N140 | N-Glycosylation | score4 | GlyGen UniProt | 16732286, 29391424 | ||
| S142 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N158 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| S164 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N596 | N-Glycosylation | score2 | GlyGen UniProt | 19159218 | ||
| N649 | N-Glycosylation | score1 | GlyGen | 23345538 | ||
| N691 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| Y697 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y816 | Phosphorylation | score2 | PRO PhosphoSitePlus | |||
| Y860 | Phosphorylation | Q02763 (TEK) | score3 | neXtProt UniProt | 11513602 | |
| Y897 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 11513602, 11080633 | ||
| Y899 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y976 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y992 | Phosphorylation | Q02763 (TEK) | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt | 26814432, 11513602, 27304216, ... | |
| T996 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1048 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus | 11513602, 11080633 | ||
| Y1080 | Phosphorylation | score2 | IntAct | 14665640 | ||
| Y1102 | Phosphorylation | Q02763 (TEK) | score4 | phospho.ELM PRO PhosphoSitePlus Signor UniProt | 14665640, 9632797, 12082108, ... | |
| N1104 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| Y1108 | Phosphorylation | Q02763 (TEK) | score4 | neXtProt phospho.ELM PRO PhosphoSitePlus Signor UniProt | 12665569, 20973951, 11513602, ... | |
| Y1113 | Phosphorylation | score4 | phospho.ELM PRO PhosphoSitePlus | 12665569, 10521483 | ||
| S1119 | Phosphorylation | score2 | PRO PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| N649 | N-Glycosylation | score1 | PRO | 23345538 | ||
| Y897 | Phosphorylation | Q02763 (TEK) | score1 | HPRD | 11080633 | |
| Y992 | Phosphorylation | score1 | HPRD | 11513602 | ||
| Y1048 | Phosphorylation | score1 | HPRD | 11513602 | ||
| Y1102 | Phosphorylation | Q02763 (TEK) | score2 | HPRD | 9632797, 10521483 | |
| Y1108 | Phosphorylation | score1 | HPRD | 11513602 | ||
| S1119 | Phosphorylation | score1 | HPRD | 11513602 |
Q02763 (TEK) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| Q02763 (TEK) | Y860 | score3 | neXtProt UniProt | 11513602 | |
| Q02763-1 (TEK) | Y897 | score1 | HPRD | 11080633 | |
| Q02763 (TEK) | Y992 | score4 | neXtProt PhosphoSitePlus UniProt | 11513602, 11080633 | |
| Q02763 (TEK) | Y1102 | score4 | HPRD Signor UniProt | 20973951, 14665640, 9632797, ... | |
| Q02763 (TEK) | Y1108 | score4 | neXtProt PhosphoSitePlus Signor UniProt | 20973951, 11513602 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000049419 (hTEK/SigPep-/Phos:1) | pY816,pY992,pY1102,pY1108,pY1113,pS1119 | PRO |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q03135 (CAV1) | Y14 | Q02763 (TEK) | unknown | eFIP | 28760776 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000002131 (hTEK/var:R849W) | Interaction | PR:P27986-1 (hPIK3R1/iso:1) | PRO | 10369874 | |
| PR:000002132 (hTEK/var:Y897S) | Interaction | PR:P27986-1 (hPIK3R1/iso:1) | PRO | 10369874 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S142 | Y142 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S142 | C142 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| S164 | L164 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| N649 | D649 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| Y816 | D816 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| Y1048 | H1048 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
 |