iPTMnet Report for Q02763 (TEK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q02763 / TIE2_HUMAN
Protein Name Angiopoietin-1 receptor precursor
Gene Name Name: TEK
Synonyms:TIE2,VMCM,VMCM1;
Organism Homo sapiens (Human)

PRO ID PR:Q02763
DAG View
PRO Name angiopoietin-1 receptor (human)
Definition An angiopoietin-1 receptor that is encoded in the genome of human.
Short Label hTEK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q02763 (TEK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T115 Phosphorylation PhosphoSitePlus
N140 N-Glycosylation GlyGen   UniProt 16732286, 29391424
S142 Phosphorylation PhosphoSitePlus
N158 N-Glycosylation GlyGen 29391424
S164 Phosphorylation PhosphoSitePlus
N596 N-Glycosylation GlyGen   UniProt 19159218
N649 N-Glycosylation GlyGen 23345538
N691 N-Glycosylation GlyGen 29391424
Y697 Phosphorylation PhosphoSitePlus
Y816 Phosphorylation PRO   PhosphoSitePlus
Y860 Phosphorylation neXtProt   UniProt 11513602
Y860 Phosphorylation Q02763 (TEK) neXtProt   UniProt 11513602
Y897 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 11513602, 11080633
Y899 Phosphorylation PhosphoSitePlus
Y976 Phosphorylation PhosphoSitePlus
Y992 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 26814432, 11513602, 27304216, ...28623351, 8382358, 11080633
Y992 Phosphorylation Q02763 (TEK) neXtProt   PhosphoSitePlus   UniProt 11513602, 11080633
T996 Phosphorylation PhosphoSitePlus
Y1048 Phosphorylation phospho.ELM   PhosphoSitePlus 11513602, 11080633
Y1080 Phosphorylation IntAct 14665640
Y1102 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 14665640, 9632797, 12082108, ...27270174, 10521483, 20973951
Y1102 Phosphorylation Q02763 (TEK) Signor   UniProt 20973951, 14665640
N1104 N-Glycosylation GlyGen 29391424
Y1108 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 12665569, 20973951, 11513602, ...10521483
Y1108 Phosphorylation Q02763 (TEK) neXtProt   PhosphoSitePlus   Signor   UniProt 20973951, 11513602
Y1113 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 12665569, 10521483
S1119 Phosphorylation PRO   PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N649 N-Glycosylation PRO 23345538
Y897 Phosphorylation HPRD 11080633
Y897 Phosphorylation Q02763 (TEK) HPRD 11080633
Y992 Phosphorylation HPRD 11513602
Y1048 Phosphorylation HPRD 11513602
Y1102 Phosphorylation HPRD 9632797, 10521483
Y1102 Phosphorylation Q02763 (TEK) HPRD 9632797, 10521483
Y1108 Phosphorylation HPRD 11513602
S1119 Phosphorylation HPRD 11513602


Q02763 (TEK) as PTM Enzyme



Substrate Site Score Source PMID
Q02763 (TEK) Y860 neXtProt   UniProt 11513602
Q02763-1 (TEK) Y897 HPRD 11080633
Q02763 (TEK) Y992 neXtProt   PhosphoSitePlus   UniProt 11513602, 11080633
Q02763 (TEK) Y1102 HPRD   Signor   UniProt 20973951, 14665640, 9632797, ...10521483
Q02763 (TEK) Y1108 neXtProt   PhosphoSitePlus   Signor   UniProt 20973951, 11513602


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049419 (hTEK/SigPep-/Phos:1) pY816,pY992,pY1102,pY1108,pY1113,pS1119 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q03135 (CAV1) Y14 Q02763 (TEK) unknown eFIP 28760776


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000002131 (hTEK/var:R849W) Interaction PR:P27986-1 (hPIK3R1/iso:1) PRO 10369874
PR:000002132 (hTEK/var:Y897S) Interaction PR:P27986-1 (hPIK3R1/iso:1) PRO 10369874


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S142 Y142 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S142 C142 Biomuta DOID:1319 / brain cancer [ cosmic ]
S164 L164 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
N649 D649 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y816 D816 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y1048 H1048 Biomuta DOID:9256 / colorectal cancer [ cosmic ]