iPTMnet Report Q01543 FLI1

Protein Information

UniProt AC / UniProt ID	Q01543 / FLI1_HUMAN
Protein Name	Friend leukemia integration 1 transcription factor
Gene Name	Name: FLI1
Organism	Homo sapiens (Human)

PRO ID	PR:Q01543 DAG View
PRO Name	Friend leukemia integration 1 transcription factor (human)
Definition	A Friend leukemia integration 1 transcription factor that is encoded in the genome of human.
Short Label	hFLI1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q01543 (FLI1) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S10 S13 S21 T35 S37 S39 Y42 K47 K67 Y70 S76 S79 S84 S86 K87 S89 K172 K217 S221 Y222 S224 S236 K240 S241 K252 Y263 T312 K325 Y332 K334 K350 K380 K397 S406 S407 T411 S412 S413 S414 S420 T424 S425 T427 R438 S450 Y451 Y452	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 1 2 4	Source Select all GlyGen PhosphoSitePlus RLIMS-P Signor phospho.ELM	PMID
S10	Phosphorylation		score1	PhosphoSitePlus
S13	Phosphorylation		score1	PhosphoSitePlus
S21	Phosphorylation		score1	PhosphoSitePlus
T35	Phosphorylation		score1	PhosphoSitePlus
S37	Phosphorylation		score1	PhosphoSitePlus
S39	Phosphorylation		score1	PhosphoSitePlus
Y42	Phosphorylation		score1	PhosphoSitePlus
K47	Ubiquitination		score1	PhosphoSitePlus
K67	Sumoylation		score1	PhosphoSitePlus
Y70	Phosphorylation		score1	PhosphoSitePlus
S76	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340
S79	Phosphorylation		score1	PhosphoSitePlus
S84	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S86	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S86	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340
K87	Ubiquitination		score1	PhosphoSitePlus
S89	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340
K172	Ubiquitination		score1	PhosphoSitePlus
K217	Ubiquitination		score1	PhosphoSitePlus
S221	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S221	Phosphorylation		score1	PhosphoSitePlus
Y222	Phosphorylation		score1	PhosphoSitePlus
S224	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S224	Phosphorylation		score1	PhosphoSitePlus
S236	Phosphorylation		score1	PhosphoSitePlus
K240	Acetylation		score1	PhosphoSitePlus
K240	Ubiquitination		score1	PhosphoSitePlus
S241	Phosphorylation		score1	PhosphoSitePlus
K252	Acetylation		score1	PhosphoSitePlus
Y263	Phosphorylation		score1	PhosphoSitePlus
T312	Phosphorylation	Q05655 (PRKCD)	score4	PhosphoSitePlus RLIMS-P Signor	24058639, 19158279, 22591006, ...22829238, 25707716, 21321929
K325	Ubiquitination		score1	PhosphoSitePlus
Y332	Phosphorylation		score1	PhosphoSitePlus
K334	Ubiquitination		score1	PhosphoSitePlus
K350	Ubiquitination		score1	PhosphoSitePlus
K380	Acetylation		score1	PhosphoSitePlus
K380	Ubiquitination		score1	PhosphoSitePlus
K397	Acetylation		score1	PhosphoSitePlus
S406	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S407	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
T411	O-Glycosylation		score1	GlyGen	27655845, 35132862, 32938750, ...29351928
S412	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S413	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S414	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S420	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
T424	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S425	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
T427	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
R438	Methylation		score1	PhosphoSitePlus
S450	Phosphorylation		score1	PhosphoSitePlus
Y451	Phosphorylation		score1	PhosphoSitePlus
Y452	Phosphorylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine By position S76 S86 S89 K380	PTM Type Select all Acetylation Phosphorylation	PTM Enzyme	Score Select all 0 2	Source Select all HPRD PRO	PMID
S76	Phosphorylation		score0	HPRD	17287340
S86	Phosphorylation		score0	HPRD	17287340
S89	Phosphorylation		score0	HPRD	17287340
K380	Acetylation	PR:000012332 (KAT2B)	score2	PRO	17884818

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000028817 (hFLI1/iso:1/Ac:1)	Sites Select all acK380	PTM Enzyme	Source Select all PRO	PMID
	PR:000028817 (hFLI1/iso:1/Ac:1)	acK380	PR:000012332 (KAT2B)	PRO	17884818

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all Q01543 (FLI1)	Site Select all By amino acid All Threonine By position T312	Interactant Select all Q09472 (EP300) Q13547 (HDAC1)	Association type Select all unknown	Source Select all eFIP	PMID
	Phosphorylation	Q01543 (FLI1)	T312	Q13547 (HDAC1)	unknown	eFIP	24058639
	Phosphorylation	Q01543 (FLI1)	T312	Q09472 (EP300)	unknown	eFIP	24058639

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position S10 S39 K47 S79 S84 S221 S236 K350 S406 S420 T424 S425 T427 R438	Variant Select all * C438 E350 F221 F406 F425 F79 G438 G84 H438 I39 L10 L420 M427 N424 R47 T39 Y236	Source Select all Biomuta	Disease [Sample source] Select all DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, tcga ] DOID:1540 / parathyroid carcinoma [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ icgc ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, tcga ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S10	*	Biomuta	DOID:1324 / lung cancer [ cosmic, tcga ]
S10	L10	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, tcga ]
S39	I39	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S39	T39	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K47	R47	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S79	F79	Biomuta	DOID:363 / uterine cancer [ icgc ]
S84	G84	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S221	F221	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S236	Y236	Biomuta	DOID:363 / uterine cancer [ icgc ]
K350	E350	Biomuta	DOID:1540 / parathyroid carcinoma [ cosmic ]
S406	F406	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S420	L420	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T424	N424	Biomuta	DOID:363 / uterine cancer [ icgc ]
S425	F425	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T427	M427	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R438	H438	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R438	C438	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
R438	G438	Biomuta	DOID:3571 / liver cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q01543 (FLI1)

Protein Information

Interactive Sequence View

Q01543 (FLI1) as Substrate

Proteoforms

PTM-dependent PPI

PTM sites affected in variants