iPTMnet Report Q01543 FLI1

Protein Information

UniProt AC / UniProt ID	Q01543 / FLI1_HUMAN
Protein Name	Friend leukemia integration 1 transcription factor
Gene Name	Name: FLI1
Organism	Homo sapiens (Human)

PRO ID	PR:Q01543 DAG View
PRO Name	Friend leukemia integration 1 transcription factor (human)
Definition	A Friend leukemia integration 1 transcription factor that is encoded in the genome of human.
Short Label	hFLI1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q01543 (FLI1) as Substrate

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S10	Phosphorylation		score1	PhosphoSitePlus
S13	Phosphorylation		score1	PhosphoSitePlus
S21	Phosphorylation		score1	PhosphoSitePlus
T35	Phosphorylation		score1	PhosphoSitePlus
S37	Phosphorylation		score1	PhosphoSitePlus
S39	Phosphorylation		score1	PhosphoSitePlus
Y42	Phosphorylation		score1	PhosphoSitePlus
K47	Ubiquitination		score1	PhosphoSitePlus
K67	Sumoylation		score1	PhosphoSitePlus
Y70	Phosphorylation		score1	PhosphoSitePlus
S76	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340
S79	Phosphorylation		score1	PhosphoSitePlus
S84	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S86	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S86	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340
K87	Ubiquitination		score1	PhosphoSitePlus
S89	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340
K172	Ubiquitination		score1	PhosphoSitePlus
K217	Ubiquitination		score1	PhosphoSitePlus
S221	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S221	Phosphorylation		score1	PhosphoSitePlus
Y222	Phosphorylation		score1	PhosphoSitePlus
S224	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S224	Phosphorylation		score1	PhosphoSitePlus
S236	Phosphorylation		score1	PhosphoSitePlus
K240	Acetylation		score1	PhosphoSitePlus
K240	Ubiquitination		score1	PhosphoSitePlus
S241	Phosphorylation		score1	PhosphoSitePlus
K252	Acetylation		score1	PhosphoSitePlus
Y263	Phosphorylation		score1	PhosphoSitePlus
T312	Phosphorylation		score4	PhosphoSitePlus RLIMS-P Signor	24058639, 19158279, 22591006, ...22829238, 25707716, 21321929
T312	Phosphorylation	Q05655 (PRKCD)	score4	PhosphoSitePlus Signor	25707716, 19158279, 21321929, ...24058639
K325	Ubiquitination		score1	PhosphoSitePlus
Y332	Phosphorylation		score1	PhosphoSitePlus
K334	Ubiquitination		score1	PhosphoSitePlus
K350	Ubiquitination		score1	PhosphoSitePlus
K380	Acetylation		score1	PhosphoSitePlus
K380	Ubiquitination		score1	PhosphoSitePlus
K397	Acetylation		score1	PhosphoSitePlus
S406	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S407	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
T411	O-Glycosylation		score1	GlyGen	27655845, 35132862, 32938750, ...29351928
S412	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S413	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S414	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S420	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
T424	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
S425	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
T427	O-Glycosylation		score1	GlyGen	27655845, 35132862, 29351928
R438	Methylation		score1	PhosphoSitePlus
S450	Phosphorylation		score1	PhosphoSitePlus
Y451	Phosphorylation		score1	PhosphoSitePlus
Y452	Phosphorylation		score1	PhosphoSitePlus

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S76	Phosphorylation		score0	HPRD	17287340
S86	Phosphorylation		score0	HPRD	17287340
S89	Phosphorylation		score0	HPRD	17287340
K380	Acetylation		score2	PRO	17884818
K380	Acetylation	PR:000012332 (KAT2B)	score2	PRO	17884818

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000028817 (hFLI1/iso:1/Ac:1)	acK380	PR:000012332 (KAT2B)	PRO	17884818

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	Q01543 (FLI1)	T312	Q13547 (HDAC1)	unknown	eFIP	24058639
	Phosphorylation	Q01543 (FLI1)	T312	Q09472 (EP300)	unknown	eFIP	24058639

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
S10	*	Biomuta	DOID:1324 / lung cancer [ cosmic, tcga ]
S10	L10	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, tcga ]
S39	I39	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S39	T39	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K47	R47	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S79	F79	Biomuta	DOID:363 / uterine cancer [ icgc ]
S84	G84	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S221	F221	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S236	Y236	Biomuta	DOID:363 / uterine cancer [ icgc ]
K350	E350	Biomuta	DOID:1540 / parathyroid carcinoma [ cosmic ]
S406	F406	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S420	L420	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T424	N424	Biomuta	DOID:363 / uterine cancer [ icgc ]
S425	F425	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T427	M427	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R438	H438	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R438	C438	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
R438	G438	Biomuta	DOID:3571 / liver cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q01543 (FLI1)

Protein Information

Interactive Sequence View

Q01543 (FLI1) as Substrate

Proteoforms

PTM-dependent PPI

PTM sites affected in variants