iPTMnet Report for Q01279 (Egfr)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q01279 / EGFR_MOUSE
Protein Name Epidermal growth factor receptor precursor
Gene Name Name: Egfr
Organism Mus musculus (Mouse)

PRO ID PR:Q01279
DAG View
PRO Name epidermal growth factor receptor (mouse)
Definition An epidermal growth factor receptor that is encoded in the genome of mouse.
Short Label mEGFR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q01279 (Egfr) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO 21186272
N175 N-Glycosylation GlyGen   UniProt 17330941
Y270 Phosphorylation phospho.ELM   PhosphoSitePlus 15016810
C311 S-Nitrosylation dbSNO 26165157
Y316 Phosphorylation phospho.ELM   PhosphoSitePlus 15378723
N352 N-Glycosylation GlyGen   UniProt 16944957, 30899004
N444 N-Glycosylation GlyGen   UniProt 16944957
K454 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
T680 Phosphorylation P28867 (Prkcd) Signor 1860884
T695 Phosphorylation P63085 (Mapk1) PhosphoSitePlus 22028470
S697 Phosphorylation PhosphoSitePlus
K710 Ubiquitination PhosphoSitePlus
Y729 Phosphorylation PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
K739 Ubiquitination PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
K854 Ubiquitination PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
Y871 Phosphorylation Q01279 (Egfr) , P05480 (Src) phospho.ELM   PhosphoSitePlus   Signor 14647453, 17043637, 16122376
K877 Ubiquitination PhosphoSitePlus
K931 Ubiquitination PhosphoSitePlus
K972 Ubiquitination PhosphoSitePlus
S993 Phosphorylation PRO   PhosphoSitePlus 21183079
T995 Phosphorylation PRO   PhosphoSitePlus 21183079
S997 Phosphorylation PRO   PhosphoSitePlus 21183079
Y1000 Phosphorylation IntAct   PhosphoSitePlus 18515860
Y1018 Phosphorylation Q01279 (Egfr) phospho.ELM   PhosphoSitePlus   Signor 16123117, 16122376
T1034 Phosphorylation PhosphoSitePlus
S1041 Phosphorylation PhosphoSitePlus
T1043 Phosphorylation PhosphoSitePlus
S1044 Phosphorylation PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
K1061 Ubiquitination PhosphoSitePlus
Y1069 Phosphorylation Q01279 (Egfr) IntAct   phospho.ELM   PhosphoSitePlus 18515860, 10635327
S1070 Phosphorylation PhosphoSitePlus
S1071 Phosphorylation PhosphoSitePlus
T1074 Phosphorylation PhosphoSitePlus
Y1092 Phosphorylation Q01279 (Egfr) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16123117, 18515860, 16122376, ...17927446
S1104 Phosphorylation PhosphoSitePlus
Y1110 Phosphorylation Q01279 (Egfr) PhosphoSitePlus   Signor 16122376
Y1138 Phosphorylation PhosphoSitePlus
S1162 Phosphorylation PRO   PhosphoSitePlus 21183079
S1166 Phosphorylation PhosphoSitePlus
Y1172 Phosphorylation Q01279 (Egfr) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 27101391, 18515860, 16902180, ...16122376
K1179 Ubiquitination PhosphoSitePlus
K1182 Ubiquitination PhosphoSitePlus
K1188 Ubiquitination PhosphoSitePlus
Y1197 Phosphorylation Q01279 (Egfr) IntAct   phospho.ELM   PhosphoSitePlus   Signor   UniProt 17242355, 12527890, 18515860, ...16122376


Q01279 (Egfr) as PTM Enzyme



Substrate Site Score Source PMID
P42567 (Eps15) Y850 phospho.ELM   PhosphoSitePlus 10953014
P97813 (Pld2) Y11 PhosphoSitePlus 9837959
Q01279 (Egfr) Y871 Signor 16122376
Q01279 (Egfr) Y1018 Signor 16122376
Q01279 (Egfr) Y1069 phospho.ELM   PhosphoSitePlus 10635327
Q01279 (Egfr) Y1092 Signor 16122376
Q01279 (Egfr) Y1110 Signor 16122376
Q01279 (Egfr) Y1172 Signor 16122376
Q01279 (Egfr) Y1197 PhosphoSitePlus   Signor 12527890, 16122376
Q91V17 (Znrf1) Y103 PhosphoSitePlus 26572622
Q9QYY0 (Gab1) Y285 phospho.ELM   PhosphoSitePlus 10734310
Q9QYY0 (Gab1) Y307 phospho.ELM   PhosphoSitePlus 10734310
Q9QYY0 (Gab1) Y373 phospho.ELM   PhosphoSitePlus 10734310
Q9QYY0 (Gab1) Y407 phospho.ELM   PhosphoSitePlus 10734310
Q9QYY0 (Gab1) Y448 phospho.ELM   PhosphoSitePlus 10734310
Q9QYY0 (Gab1) Y473 phospho.ELM   PhosphoSitePlus 10734310
Q9QYY0 (Gab1) Y590 phospho.ELM   PhosphoSitePlus 10734310
Q9QYY0 (Gab1) Y628 phospho.ELM   PhosphoSitePlus 10734310
Q9QYY0 (Gab1) Y660 phospho.ELM   PhosphoSitePlus 10734310


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044844 (mEGFR/PhosRes+) p PRO 21186272
PR:000049816 (mEGFR/SigPep-/Phos:1) pS993 PRO 21183079
PR:000049817 (mEGFR/SigPep-/Phos:2) pT995 PRO 21183079
PR:000049818 (mEGFR/SigPep-/Phos:3) pS997 PRO 21183079
PR:000049819 (mEGFR/SigPep-/Phos:4) pS1162 PRO 21183079


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P42227 (Stat3) Y705 Q01279 (Egfr) unknown eFIP 31217524
Phosphorylation P98083 (Shc1) S36 Q01279 (Egfr) increased_association eFIP 18174162