iPTMnet Report Q01279 Egfr

Protein Information

UniProt AC / UniProt ID	Q01279 / EGFR_MOUSE
Protein Name	Epidermal growth factor receptor precursor
Gene Name	Name: Egfr
Organism	Mus musculus (Mouse)

PRO ID	PR:Q01279 DAG View
PRO Name	epidermal growth factor receptor (mouse)
Definition	An epidermal growth factor receptor that is encoded in the genome of mouse.
Short Label	mEGFR
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q01279 (Egfr) as Substrate

Q01279

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position N175 Y270 C311 Y316 N352 N444 K454 K487 T680 T695 S697 K710 Y729 K730 K739 K741 K747 K759 K848 K854 K862 K869 Y871 K877 K931 K972 S993 T995 S997 Y1000 Y1018 T1034 S1041 T1043 S1044 S1057 K1061 Y1069 S1070 S1071 T1074 Y1092 S1104 Y1110 Y1138 S1162 S1166 Y1172 K1179 K1182 K1188 Y1197	PTM Type Select all N-Glycosylation Phosphorylation S-Nitrosylation Ubiquitination	PTM Enzyme Select all P05480 (Src) P28867 (Prkcd) P63085 (Mapk1) Q01279 (Egfr)	Score Select all 0 1 2 3 4	Source Select all GlyGen IntAct PRO PhosphoSitePlus RLIMS-P Signor UniProt dbSNO phospho.ELM	PMID
	Phosphorylation		score2	PRO	21186272
N175	N-Glycosylation		score2	GlyGen UniProt	17330941
Y270	Phosphorylation		score3	phospho.ELM PhosphoSitePlus	15016810
C311	S-Nitrosylation		score0	dbSNO	26165157
Y316	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	15378723
N352	N-Glycosylation		score2	GlyGen UniProt	16944957, 30899004
N444	N-Glycosylation		score2	GlyGen UniProt	16944957
K454	Ubiquitination		score1	PhosphoSitePlus
K487	Ubiquitination		score1	PhosphoSitePlus
T680	Phosphorylation		score1	Signor	1860884
T680	Phosphorylation	P28867 (Prkcd)	score1	Signor	1860884
T695	Phosphorylation		score1	PhosphoSitePlus	22028470
T695	Phosphorylation	P63085 (Mapk1)	score1	PhosphoSitePlus	22028470
S697	Phosphorylation		score1	PhosphoSitePlus
K710	Ubiquitination		score1	PhosphoSitePlus
Y729	Phosphorylation		score1	PhosphoSitePlus
K730	Ubiquitination		score1	PhosphoSitePlus
K739	Ubiquitination		score1	PhosphoSitePlus
K741	Ubiquitination		score1	PhosphoSitePlus
K747	Ubiquitination		score1	PhosphoSitePlus
K759	Ubiquitination		score1	PhosphoSitePlus
K848	Ubiquitination		score1	PhosphoSitePlus
K854	Ubiquitination		score1	PhosphoSitePlus
K862	Ubiquitination		score1	PhosphoSitePlus
K869	Ubiquitination		score1	PhosphoSitePlus
Y871	Phosphorylation		score4	phospho.ELM PhosphoSitePlus Signor	14647453, 17043637, 16122376
Y871	Phosphorylation	P05480 (Src)	score2	PhosphoSitePlus	17043637
Y871	Phosphorylation	Q01279 (Egfr)	score1	Signor	16122376
K877	Ubiquitination		score1	PhosphoSitePlus
K931	Ubiquitination		score1	PhosphoSitePlus
K972	Ubiquitination		score1	PhosphoSitePlus
S993	Phosphorylation		score2	PRO PhosphoSitePlus	21183079
T995	Phosphorylation		score2	PRO PhosphoSitePlus	21183079
S997	Phosphorylation		score2	PRO PhosphoSitePlus	21183079
Y1000	Phosphorylation		score3	IntAct PhosphoSitePlus	18515860
Y1018	Phosphorylation		score4	phospho.ELM PhosphoSitePlus Signor	16123117, 16122376
Y1018	Phosphorylation	Q01279 (Egfr)	score1	Signor	16122376
T1034	Phosphorylation		score1	PhosphoSitePlus
S1041	Phosphorylation		score1	PhosphoSitePlus
T1043	Phosphorylation		score1	PhosphoSitePlus
S1044	Phosphorylation		score1	PhosphoSitePlus
S1057	Phosphorylation		score1	PhosphoSitePlus
K1061	Ubiquitination		score1	PhosphoSitePlus
Y1069	Phosphorylation		score4	IntAct phospho.ELM PhosphoSitePlus	18515860, 10635327
Y1069	Phosphorylation	Q01279 (Egfr)	score3	phospho.ELM PhosphoSitePlus	10635327
S1070	Phosphorylation		score1	PhosphoSitePlus
S1071	Phosphorylation		score1	PhosphoSitePlus
T1074	Phosphorylation		score1	PhosphoSitePlus
Y1092	Phosphorylation		score4	IntAct phospho.ELM PhosphoSitePlus RLIMS-P Signor	16123117, 18515860, 16122376, ...17927446
Y1092	Phosphorylation	Q01279 (Egfr)	score1	Signor	16122376
S1104	Phosphorylation		score1	PhosphoSitePlus
Y1110	Phosphorylation		score3	PhosphoSitePlus Signor	16122376
Y1110	Phosphorylation	Q01279 (Egfr)	score1	Signor	16122376
Y1138	Phosphorylation		score1	PhosphoSitePlus
S1162	Phosphorylation		score2	PRO PhosphoSitePlus	21183079
S1166	Phosphorylation		score1	PhosphoSitePlus
Y1172	Phosphorylation		score4	IntAct phospho.ELM PhosphoSitePlus RLIMS-P Signor	27101391, 18515860, 16902180, ...16122376
Y1172	Phosphorylation	Q01279 (Egfr)	score1	Signor	16122376
K1179	Ubiquitination		score1	PhosphoSitePlus
K1182	Ubiquitination		score1	PhosphoSitePlus
K1188	Ubiquitination		score1	PhosphoSitePlus
Y1197	Phosphorylation		score4	IntAct phospho.ELM PhosphoSitePlus Signor UniProt	17242355, 12527890, 18515860, ...16122376
Y1197	Phosphorylation	Q01279 (Egfr)	score4	PhosphoSitePlus Signor	12527890, 16122376

Q01279 (Egfr) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all P42567 (Eps15) P97813 (Pld2) Q01279 (Egfr) Q91V17 (Znrf1) Q9QYY0 (Gab1)	Site Select all By amino acid All Tyrosine By position Y11 Y103 Y285 Y307 Y373 Y407 Y448 Y473 Y590 Y628 Y660 Y850 Y871 Y1018 Y1069 Y1092 Y1110 Y1172 Y1197	Score Select all 1 2 3 4	Source Select all PhosphoSitePlus Signor phospho.ELM	PMID
P42567 (Eps15)	Y850	score3	phospho.ELM PhosphoSitePlus	10953014
P97813 (Pld2)	Y11	score2	PhosphoSitePlus	9837959
Q01279 (Egfr)	Y871	score1	Signor	16122376
Q01279 (Egfr)	Y1018	score1	Signor	16122376
Q01279 (Egfr)	Y1069	score3	phospho.ELM PhosphoSitePlus	10635327
Q01279 (Egfr)	Y1092	score1	Signor	16122376
Q01279 (Egfr)	Y1110	score1	Signor	16122376
Q01279 (Egfr)	Y1172	score1	Signor	16122376
Q01279 (Egfr)	Y1197	score4	PhosphoSitePlus Signor	12527890, 16122376
Q91V17 (Znrf1)	Y103	score2	PhosphoSitePlus	26572622
Q9QYY0 (Gab1)	Y285	score3	phospho.ELM PhosphoSitePlus	10734310
Q9QYY0 (Gab1)	Y307	score3	phospho.ELM PhosphoSitePlus	10734310
Q9QYY0 (Gab1)	Y373	score3	phospho.ELM PhosphoSitePlus	10734310
Q9QYY0 (Gab1)	Y407	score3	phospho.ELM PhosphoSitePlus	10734310
Q9QYY0 (Gab1)	Y448	score3	phospho.ELM PhosphoSitePlus	10734310
Q9QYY0 (Gab1)	Y473	score3	phospho.ELM PhosphoSitePlus	10734310
Q9QYY0 (Gab1)	Y590	score3	phospho.ELM PhosphoSitePlus	10734310
Q9QYY0 (Gab1)	Y628	score3	phospho.ELM PhosphoSitePlus	10734310
Q9QYY0 (Gab1)	Y660	score3	phospho.ELM PhosphoSitePlus	10734310

Proteoforms

Search:

PRO ID (Short Label) Select all PR:000044844 (mEGFR/PhosRes+) PR:000049816 (mEGFR/SigPep-/Phos:1) PR:000049817 (mEGFR/SigPep-/Phos:2) PR:000049818 (mEGFR/SigPep-/Phos:3) PR:000049819 (mEGFR/SigPep-/Phos:4)	Sites Select all p pS1162 pS993 pS997 pT995	Source Select all PRO	PMID
PR:000044844 (mEGFR/PhosRes+)	p	PRO	21186272
PR:000049816 (mEGFR/SigPep-/Phos:1)	pS993	PRO	21183079
PR:000049817 (mEGFR/SigPep-/Phos:2)	pT995	PRO	21183079
PR:000049818 (mEGFR/SigPep-/Phos:3)	pS997	PRO	21183079
PR:000049819 (mEGFR/SigPep-/Phos:4)	pS1162	PRO	21183079

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all P42227 (Stat3) P98083 (Shc1)	Site Select all By amino acid All Serine All Tyrosine By position S36 Y705	Interactant Select all Q01279 (Egfr)	Association type Select all increased_association unknown	Source Select all eFIP	PMID
	Phosphorylation	P42227 (Stat3)	Y705	Q01279 (Egfr)	unknown	eFIP	31217524
	Phosphorylation	P98083 (Shc1)	S36	Q01279 (Egfr)	increased_association	eFIP	18174162

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q01279 (Egfr)

Protein Information

Interactive Sequence View

Q01279 (Egfr) as Substrate

Q01279 (Egfr) as PTM Enzyme

Proteoforms

PTM-dependent PPI