iPTMnet Report for P81133 (SIM1)
Protein Information
UniProt AC / UniProt ID | P81133 / SIM1_HUMAN |
Protein Name | Single-minded homolog 1 |
Gene Name | Name: SIM1 Synonyms:BHLHE14; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P81133 |
PRO Name | single-minded homolog 1 (human) |
Definition | A single-minded homolog 1 that is encoded in the genome of human. |
Short Label | hSIM1 |
Category | organism-gene |
P81133 (SIM1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S31 | Phosphorylation | score1 | PhosphoSitePlus | |||
T34 | Phosphorylation | score1 | PhosphoSitePlus | |||
S35 | Phosphorylation | score1 | PhosphoSitePlus | |||
S343 | Phosphorylation | score1 | PhosphoSitePlus | |||
S350 | Phosphorylation | score1 | PhosphoSitePlus | |||
S355 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y356 | Phosphorylation | score1 | PhosphoSitePlus | |||
S358 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y477 | Phosphorylation | score1 | PhosphoSitePlus | |||
T481 | Phosphorylation | score1 | PhosphoSitePlus | |||
S642 | Phosphorylation | score1 | PhosphoSitePlus | |||
S670 | Phosphorylation | score1 | PhosphoSitePlus | |||
S737 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S31 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S31 | L31 | Biomuta | DOID:363 / uterine cancer [ cosmic ] DOID:4362 / cervical cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S35 | L35 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S343 | F343 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S355 | F355 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
T481 | R481 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T481 | M481 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
S737 | P737 | Biomuta | DOID:263 / kidney cancer [ cosmic ] |