Protein Information

Cytoscape View


UniProt AC / UniProt ID P81133 / SIM1_HUMAN
Protein Name Single-minded homolog 1
Gene Name Name: SIM1
Synonyms:BHLHE14;
Organism Homo sapiens (Human)

PRO ID PR:P81133
DAG View
PRO Name single-minded homolog 1 (human)
Definition A single-minded homolog 1 that is encoded in the genome of human.
Short Label hSIM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P81133 (SIM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
Y477 Phosphorylation PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S31 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S31 L31 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4362 / cervical cancer [ icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S35 L35 Biomuta DOID:1909 / melanoma [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
S343 F343 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S355 F355 Biomuta DOID:3070 / malignant glioma [ cosmic ]
T481 R481 Biomuta DOID:1324 / lung cancer [ cosmic ]
T481 M481 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S737 P737 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]