Protein Information

Cytoscape View


UniProt AC / UniProt ID P68036 / UB2L3_HUMAN
Protein Name Ubiquitin-conjugating enzyme E2 L3
Gene Name Name: UBE2L3
Synonyms:UBCE7,UBCH7;
Organism Homo sapiens (Human)

PRO ID PR:P68036
DAG View
PRO Name ubiquitin-conjugating enzyme E2 L3 (human)
Definition A ubiquitin-conjugating enzyme E2 L3 that is encoded in the genome of human.
Short Label hUBE2L3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P68036 (UBE2L3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Acetylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
K20 Acetylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
C86 S-Nitrosylation dbSNO 19483679, 22178444
K96 Acetylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus   UniProt 19608861
K131 Ubiquitination PhosphoSitePlus
K138 Acetylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K145 Acetylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K9 N9 Biomuta DOID:3571 / liver cancer [ icgc ]
K48 M48 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K48 T48 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K67 T67 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K82 R82 Biomuta DOID:3571 / liver cancer [ tcga ]