iPTMnet Report for P63279 (UBE2I)
Protein Information
| UniProt AC / UniProt ID | P63279 / UBC9_HUMAN |
| Protein Name | SUMO-conjugating enzyme UBC9 |
| Gene Name | Name: UBE2I Synonyms:UBC9,UBCE9; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P63279 |
| PRO Name | SUMO-conjugating enzyme UBC9 (human) |
| Definition | A SUMO-conjugating enzyme UBC9 that is encoded in the genome of human. |
| Short Label | hUBE2I |
| Category | organism-gene |
DAG ViewP63279 (UBE2I) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Acetylation | score1 | UniProt | 19413330, 22814378 | ||
| S2 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20058876 | ||
| K14 | Sumoylation | score1 | PhosphoSitePlus | |||
| K18 | Sumoylation | score1 | PhosphoSitePlus | |||
| K18 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T35 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K48 | Sumoylation | score1 | PhosphoSitePlus | |||
| K49 | Sumoylation | score1 | PhosphoSitePlus | |||
| K49 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K59 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K65 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K65 | Sumoylation | score1 | PhosphoSitePlus | |||
| K65 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S70 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 22509284 | ||
| S71 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 24953629, 23186163, 22407595, ... | ||
| S71 | Phosphorylation | P06493 (CDK1) | score3 | PhosphoSitePlus | 22407595, 22509284 | |
| K74 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C93 | Methylation | score1 | IEDB | 31844290 | ||
| K101 | Sumoylation | score1 | PhosphoSitePlus | |||
| K146 | Sumoylation | score1 | PhosphoSitePlus | |||
| K153 | Sumoylation | score1 | PhosphoSitePlus | |||
| K154 | Sumoylation | score1 | PhosphoSitePlus |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:P29590-4 (hPML/iso:4) | Interaction | PR:P63279 (hUBE2I) | PRO | 9885291 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T35 | M35 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| T35 | K35 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K49 | E49 | Biomuta | [ cosmic ] DOID:1115 / sarcoma [ icgc ] | |
| S70 | F70 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S71 | P71 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S71 | L71 | Biomuta | [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| C93 | Y93 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] |
