iPTMnet Report for P63279 (UBE2I)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P63279 / UBC9_HUMAN
Protein Name SUMO-conjugating enzyme UBC9
Gene Name Name: UBE2I
Synonyms:UBC9,UBCE9;
Organism Homo sapiens (Human)

PRO ID PR:P63279
DAG View
PRO Name SUMO-conjugating enzyme UBC9 (human)
Definition A SUMO-conjugating enzyme UBC9 that is encoded in the genome of human.
Short Label hUBE2I
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P63279 (UBE2I) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378
S2 Phosphorylation HPRD   PhosphoSitePlus 20058876
K14 Sumoylation PhosphoSitePlus
K18 Sumoylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
K48 Sumoylation PhosphoSitePlus
K49 Sumoylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K65 Acetylation PhosphoSitePlus   UniProt 19608861
K65 Sumoylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus   RLIMS-P 22509284
S71 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 24953629, 23186163, 22407595, ...22509284
K74 Ubiquitination PhosphoSitePlus
C93 Methylation IEDB 31844290
K101 Sumoylation PhosphoSitePlus
K146 Sumoylation PhosphoSitePlus
K153 Sumoylation PhosphoSitePlus
K154 Sumoylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P29590-4 (hPML/iso:4) Interaction PR:P63279 (hUBE2I) PRO 9885291


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T35 M35 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T35 K35 Biomuta DOID:4159 / skin cancer [ cosmic ]
K49 E49 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S70 F70 Biomuta DOID:4159 / skin cancer [ cosmic ]
S71 P71 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S71 L71 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
C93 Y93 Biomuta DOID:4606 / bile duct cancer [ cosmic ]