Protein Information

Cytoscape View


UniProt AC / UniProt ID P63241 / IF5A1_HUMAN
Protein Name Eukaryotic translation initiation factor 5A-1
Gene Name Name: EIF5A
Organism Homo sapiens (Human)

PRO ID PR:P63241
DAG View
PRO Name eukaryotic translation initiation factor 5A-1 (human)
Definition A eukaryotic translation initiation factor 5A-1 that is encoded in the genome of human.
Short Label hEIF5A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P63241 (EIF5A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
K27 Acetylation PhosphoSitePlus
K27 Sumoylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
K34 Sumoylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K39 Sumoylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
K47 Acetylation PhosphoSitePlus   UniProt 19379712
K47 Ubiquitination PhosphoSitePlus
K55 Acetylation PhosphoSitePlus
T65 Phosphorylation PhosphoSitePlus
K67 Acetylation PhosphoSitePlus
K67 Sumoylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Methylation PhosphoSitePlus
K68 Sumoylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K85 Sumoylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
Y98 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
S105 O-Glycosylation GlyGen 23301498, 16408927, 29351928, ...32119511
R113 Methylation PhosphoSitePlus
K121 Acetylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K126 Sumoylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation HPRD 18491316
S44 Phosphorylation HPRD 20068231
S46 Phosphorylation HPRD 19413330, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 * Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S15 L15 Biomuta DOID:1324 / lung cancer [ tcga ]
S23 L23 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]
K27 T27 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S46 L46 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K85 * Biomuta DOID:3070 / malignant glioma [ tcga ]
Y98 H98 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S100 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R113 H113 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R113 C113 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K126 T126 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y127 C127 Biomuta DOID:1612 / breast cancer [ cosmic ]
K150 E150 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]