iPTMnet Report for P63000 (RAC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P63000 / RAC1_HUMAN
Protein Name Ras-related C3 botulinum toxin substrate 1 precursor
Gene Name Name: RAC1
Synonyms:TC25;ORFNames:MIG5;
Organism Homo sapiens (Human)

PRO ID PR:P63000
DAG View
PRO Name Ras-related C3 botulinum toxin substrate 1 (human)
Definition A Ras-related C3 botulinum toxin substrate 1 that is encoded in the genome of human.
Short Label hRAC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P63000 (RAC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
T35 O-Glycosylation UniProt 7775453, 24905543, 7777059, ...8810274, 19744486
Y64 Phosphorylation PhosphoSitePlus   RLIMS-P 22163037
Y64 Phosphorylation P12931 (SRC) PhosphoSitePlus 22163037
Y64 Phosphorylation Q05397 (PTK2) PhosphoSitePlus 22163037
S71 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24750242, 23274900, 10617634, ...19908241, 30828687, 22970203, 18669648, 16831194, 31480268, 23071436, 25888628, 20648624, 31515469, 24571616
S71 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 10617634
S89 Phosphorylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
R102 Methylation PhosphoSitePlus
C105 Methylation IEDB 31844290
C105 S-Nitrosylation dbSNO 26338901
T108 Phosphorylation PhosphoSitePlus   RLIMS-P 24043306, 33417283
T108 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 24043306
K116 Ubiquitination PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
K123 Methylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K130 Methylation PhosphoSitePlus
K133 Acetylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus   UniProt 18093184
K153 Acetylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
C157 S-Nitrosylation dbSNO 26338901
T161 Phosphorylation PhosphoSitePlus
R163 Methylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus   UniProt 23512198
T167 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
C178 Methylation IEDB 31844290
C178 S-Nitrosylation dbSNO 19483679
K183 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation HPRD 10617634
S71 Phosphorylation P31749 (AKT1) HPRD 10617634
Site PTM Type PTM Enzyme Score Source PMID
Y64 Phosphorylation PhosphoSitePlus
S71 Phosphorylation HPRD   PhosphoSitePlus 18669648, 10617634
S71 Phosphorylation P31749 (AKT1) HPRD 18669648, 10617634
T75 Phosphorylation PhosphoSitePlus
Y80 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P46940 (IQGAP1) S1441 P63000 (RAC1) increased_association eFIP 28739799
Phosphorylation P52565 (ARHGDIA) S174 P63000 (RAC1) unknown eFIP 29121646
Phosphorylation P52566 (ARHGDIB) S31 P63000 (RAC1) inhibited_association eFIP 22469974
Phosphorylation P63000 (RAC1) T108 P19174 (PLCG1) inhibited_association eFIP 24043306
Phosphorylation Q86UR1 (NOXA1) S282 P63000 (RAC1) decreased_association eFIP 20110267


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S71 F71 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
S89 L89 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, icgc ] [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K116 N116 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
C157 Y157 Biomuta DOID:1324 / lung cancer [ cosmic ]
R163 Q163 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R163 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T167 K167 Biomuta DOID:3571 / liver cancer [ cosmic ]