Protein Information

Cytoscape View

UniProt AC / UniProt ID P63000 / RAC1_HUMAN
Protein Name Ras-related C3 botulinum toxin substrate 1 precursor
Gene Name Name: RAC1
Organism Homo sapiens (Human)

PRO ID PR:P63000
DAG View
PRO Name Ras-related C3 botulinum toxin substrate 1 (human)
Definition A Ras-related C3 botulinum toxin substrate 1 that is encoded in the genome of human.
Short Label hRAC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P63000 (RAC1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation P12931 (SRC) , Q05397 (PTK2) PhosphoSitePlus   RLIMS-P 22163037
S71 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 24750242, 10617634, 19908241, ...24571616, 22970203, 18669648, 23071436, 16831194, 20648624, 25888628
S89 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
R102 Methylation PhosphoSitePlus
C105 S-Nitrosylation dbSNO 26338901
T108 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   RLIMS-P 26816343, 24043306
K116 Ubiquitination PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
K123 Methylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K130 Methylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus   UniProt 18093184
K153 Ubiquitination PhosphoSitePlus
C157 S-Nitrosylation dbSNO 26338901
T161 Phosphorylation PhosphoSitePlus
R163 Methylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
T167 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
C178 S-Nitrosylation dbSNO 19483679
K183 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation P31749 (AKT1) HPRD 10617634
Site PTM Type PTM Enzyme Score Source PMID
Y64 Phosphorylation PhosphoSitePlus
S71 Phosphorylation P31749 (AKT1) HPRD   PhosphoSitePlus 18669648, 10617634
T75 Phosphorylation PhosphoSitePlus
Y80 Phosphorylation PhosphoSitePlus

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P52565 (ARHGDIA) S34 P63000 (RAC1) unknown eFIP 22918940
Phosphorylation P52566 (ARHGDIB) S31 P63000 (RAC1) inhibited_association eFIP 22469974
Phosphorylation Q86UR1 (NOXA1) S282 P63000 (RAC1) decreased_association eFIP 20110267
Phosphorylation Q86UR1 (NOXA1) S172 P63000 (RAC1) decreased_association eFIP 20110267

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S71 F71 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K116 R116 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K116 N116 Biomuta DOID:11934 / head and neck cancer [ tcga ]
C157 Y157 Biomuta DOID:1324 / lung cancer [ cosmic ]
R163 Q163 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R163 * Biomuta DOID:363 / uterine cancer [ tcga ]
T167 K167 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]