iPTMnet Report for P62993 (GRB2)
Protein Information
| UniProt AC / UniProt ID | P62993 / GRB2_HUMAN |
| Protein Name | Growth factor receptor-bound protein 2 |
| Gene Name | Name: GRB2 Synonyms:ASH; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P62993 |
| PRO Name | growth factor receptor-bound protein 2 (human) |
| Definition | A growth factor receptor-bound protein 2 that is encoded in the genome of human. |
| Short Label | hGRB2 |
| Category | organism-gene |
DAG ViewP62993 (GRB2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 22814378 | ||
| K6 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| Y7 | Phosphorylation | score2 | PhosphoSitePlus | 19273609 | ||
| Y7 | Phosphorylation | O60674 (JAK2) | score2 | PhosphoSitePlus | 19273609 | |
| K10 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S18 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K20 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C32 | Methylation | score1 | IEDB | 31844290 | ||
| C32 | S-Nitrosylation | score0 | dbSNO | 19483679 | ||
| Y37 | Phosphorylation | score2 | PhosphoSitePlus | 19273609 | ||
| Y37 | Phosphorylation | O60674 (JAK2) | score2 | PhosphoSitePlus | 19273609 | |
| K38 | Acetylation | score1 | PhosphoSitePlus | |||
| K38 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K44 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K50 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| Y52 | Phosphorylation | score2 | PhosphoSitePlus | 19273609 | ||
| Y52 | Phosphorylation | O60674 (JAK2) | score2 | PhosphoSitePlus | 19273609 | |
| K56 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K64 | Acetylation | score1 | PhosphoSitePlus | |||
| K69 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K76 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R78 | Methylation | score1 | PhosphoSitePlus | |||
| S88 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S90 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K109 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K109 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K117 | Acetylation | score1 | PhosphoSitePlus | |||
| T159 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y160 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P Signor | 26103942, 33795832, 9016807, ... | ||
| Y160 | Phosphorylation | P12931 (SRC) | score1 | Signor | 20554525 | |
| Y160 | Phosphorylation | Q9UM73 (ALK) | score3 | PhosphoSitePlus Signor | 20554525 | |
| K195 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y209 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 22726438, 19273609, 11726515, ... | ||
| Y209 | Phosphorylation | A9UF07 (BCR/ABL fusion) | score2 | PhosphoSitePlus | 11726515 | |
| Y209 | Phosphorylation | O60674 (JAK2) | score2 | PhosphoSitePlus | 19273609 | |
| Y209 | Phosphorylation | P00533 (EGFR) | score3 | phospho.ELM Signor | 11726515 | |
| Y209 | Phosphorylation | P21802 (FGFR2) | score2 | neXtProt | 22726438 | |
| T211 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
| R215 | Methylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y160 | Phosphorylation | score1 | HPRD | 9016807 | ||
| Y160 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 9016807 | |
| Y209 | Phosphorylation | score0 | HPRD | 17081983 | ||
| T211 | Phosphorylation | score0 | HPRD | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y52 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y119 | Phosphorylation | score1 | HPRD | 9016807 | ||
| Y119 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 9016807 | |
| Y168 | Phosphorylation | score1 | HPRD | 11726515 | ||
| Y168 | Phosphorylation | P00533 (EGFR) | score1 | HPRD | 11726515 | |
| T170 | Phosphorylation | score0 | HPRD | 18669648 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | O75674 (TOM1L1) | Y460 | P62993 (GRB2) | unknown | eFIP | 19798056 | |
| Phosphorylation | P07949 (RET) | Y1096 | P62993 (GRB2) | unknown | eFIP | 8621380 | |
| Phosphorylation | Q05397 (PTK2) | Y397 | P62993 (GRB2) | increased_association | eFIP | 9148935 | |
| Phosphorylation | Q75VX8 (GAREM2) | Y551 | P62993 (GRB2) | unknown | eFIP | 24003223 | |
| Phosphorylation | Q8TDY4 (ASAP3) | Y733 | P62993 (GRB2) | unknown | eFIP | 22027826 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000025633 (hMED28/iso:1/Phos:1) | Interaction | PR:P62993 (hGRB2) | PRO | 16899217 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y7 | D7 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] | |
| K20 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K26 | E26 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K117 | R117 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y119 | H119 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| Y160 | H160 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| Y168 | H168 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y209 | H209 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| R215 | Q215 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] |
