Protein Information

Cytoscape View


UniProt AC / UniProt ID P62993 / GRB2_HUMAN
Protein Name Growth factor receptor-bound protein 2
Gene Name Name: GRB2
Synonyms:ASH;
Organism Homo sapiens (Human)

PRO ID PR:P62993
DAG View
PRO Name growth factor receptor-bound protein 2 (human)
Definition A growth factor receptor-bound protein 2 that is encoded in the genome of human.
Short Label hGRB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P62993 (GRB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K6 Acetylation PhosphoSitePlus   UniProt 19608861
Y7 Phosphorylation O60674 (JAK2) PhosphoSitePlus 19273609
K10 Ubiquitination PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
C32 S-Nitrosylation dbSNO 19483679
Y37 Phosphorylation O60674 (JAK2) PhosphoSitePlus 19273609
K38 Acetylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K50 Acetylation PhosphoSitePlus   UniProt 19608861
Y52 Phosphorylation O60674 (JAK2) PhosphoSitePlus 19273609
K56 Ubiquitination PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
R78 Methylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K109 Acetylation PhosphoSitePlus   UniProt 19608861
K109 Ubiquitination PhosphoSitePlus
K117 Acetylation PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
Y160 Phosphorylation Q9UM73 (ALK) , P12931 (SRC) PhosphoSitePlus   RLIMS-P   Signor 26103942, 9016807, 20554525
K195 Ubiquitination PhosphoSitePlus
Y209 Phosphorylation P21802 (FGFR2) , O60674 (JAK2) , A9UF07 (BCR/ABL fusion) , P00533 (EGFR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 22726438, 19273609, 11726515, ...23420874, 22327338
T211 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
R215 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y160 Phosphorylation P12931 (SRC) HPRD 9016807
Y209 Phosphorylation HPRD 17081983
T211 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y52 Phosphorylation PhosphoSitePlus
Y119 Phosphorylation P12931 (SRC) HPRD 9016807
Y168 Phosphorylation P00533 (EGFR) HPRD 11726515
T170 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75674 (TOM1L1) Y460 P62993 (GRB2) unknown eFIP 19798056
Phosphorylation P07949 (RET) Y1096 P62993 (GRB2) unknown eFIP 8621380
Phosphorylation Q05397 (PTK2) Y397 P62993 (GRB2) increased_association eFIP 9148935
Phosphorylation Q75VX8 (GAREM2) Y551 P62993 (GRB2) unknown eFIP 24003223
Phosphorylation Q8TDY4 (ASAP3) Y733 P62993 (GRB2) unknown eFIP 22027826


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025633 (hMED28/iso:1/Phos:1) Interaction PR:P62993 (hGRB2) PRO 16899217


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y7 D7 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K26 E26 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y37 * Biomuta DOID:3571 / liver cancer [ icgc ]
K117 R117 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R215 Q215 Biomuta DOID:1612 / breast cancer [ icgc, tcga ]