iPTMnet Report for P58753 (TIRAP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P58753 / TIRAP_HUMAN
Protein Name Toll/interleukin-1 receptor domain-containing adapter protein
Gene Name Name: TIRAP
Synonyms:MAL;
Organism Homo sapiens (Human)

PRO ID PR:P58753
DAG View
PRO Name Toll/interleukin-1 receptor domain-containing adapter protein (human)
Definition A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human.
Short Label hTIRAP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P58753 (TIRAP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
T28 Phosphorylation Q9NWZ3 (IRAK4) , P51617 (IRAK1) neXtProt   PhosphoSitePlus   RLIMS-P 28225045, 29434596, 20400509
Y86 Phosphorylation Q06187 (BTK) neXtProt   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P 35379857, 16439361, 24840642, ...20822478
Y106 Phosphorylation Q06187 (BTK) neXtProt   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P 35379857, 16439361, 24840642, ...20822478
T124 Phosphorylation PhosphoSitePlus
Y159 Phosphorylation PRO   RLIMS-P 35379857
Y187 Phosphorylation Q06187 (BTK) neXtProt   PRO   PhosphoSitePlus   RLIMS-P 35379857, 16439361
Y216 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049460 (hTIRAP/Phos:2) pY86,pY106,pY159,pY187 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15109 (AGER) S391 P58753 (TIRAP) increased_association eFIP 21829704


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T28 P28 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T124 A124 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y159 C159 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S221 R221 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]