Protein Information

Cytoscape View


UniProt AC / UniProt ID P58753 / TIRAP_HUMAN
Protein Name Toll/interleukin-1 receptor domain-containing adapter protein
Gene Name Name: TIRAP
Synonyms:MAL;
Organism Homo sapiens (Human)

PRO ID PR:P58753
DAG View
PRO Name Toll/interleukin-1 receptor domain-containing adapter protein (human)
Definition A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human.
Short Label hTIRAP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P58753 (TIRAP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
T28 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 28225045, 29434596, 20400509
T28 Phosphorylation P51617 (IRAK1) neXtProt 20400509
T28 Phosphorylation Q9NWZ3 (IRAK4) neXtProt 20400509
Y86 Phosphorylation neXtProt   PRO   PhosphoSitePlus   RLIMS-P+ 16439361, 24840642
Y86 Phosphorylation Q06187 (BTK) neXtProt   PhosphoSitePlus   RLIMS-P+ 16439361, 24840642
Y106 Phosphorylation neXtProt   PRO   PhosphoSitePlus   RLIMS-P+ 16439361, 24840642
Y106 Phosphorylation Q06187 (BTK) neXtProt   PhosphoSitePlus   RLIMS-P+ 16439361, 24840642
T124 Phosphorylation PhosphoSitePlus
Y159 Phosphorylation PRO
Y187 Phosphorylation neXtProt   PRO   PhosphoSitePlus 16439361
Y187 Phosphorylation Q06187 (BTK) neXtProt   PhosphoSitePlus 16439361
Y216 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049460 (hTIRAP/Phos:2) pY86,pY106,pY159,pY187 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15109 (AGER) S391 P58753 (TIRAP) increased_association eFIP 21829704


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T28 P28 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T124 A124 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S221 R221 Biomuta DOID:363 / uterine cancer [ tcga ]