iPTMnet Report for P56817 (BACE1)
Protein Information
| UniProt AC / UniProt ID | P56817 / BACE1_HUMAN |
| Protein Name | Beta-secretase 1 precursor |
| Gene Name | Name: BACE1 Synonyms:BACE,KIAA1149; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P56817 |
| PRO Name | beta-secretase 1 (human) |
| Definition | A beta-secretase 1 that is encoded in the genome of human. |
| Short Label | hBACE1 |
| Category | organism-gene |
DAG ViewP56817 (BACE1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T47 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S59 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S71 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S83 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K126 | Acetylation | score4 | PRO PhosphoSitePlus UniProt | 17425515, 19011241 | ||
| K136 | Acetylation | score1 | PhosphoSitePlus | |||
| N153 | N-Glycosylation | score2 | GlyGen | 10887202 | ||
| N172 | N-Glycosylation | score2 | GlyGen | 10887202 | ||
| N223 | N-Glycosylation | score2 | GlyGen | 10887202 | ||
| T252 | Phosphorylation | score2 | PhosphoSitePlus | 26317805 | ||
| T252 | Phosphorylation | Q00535 (CDK5) | score2 | PhosphoSitePlus | 26317805 | |
| Y260 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K275 | Acetylation | score4 | PRO PhosphoSitePlus UniProt | 17425515, 19011241 | ||
| K279 | Acetylation | score4 | PRO PhosphoSitePlus UniProt | 17425515, 19011241 | ||
| K285 | Acetylation | score4 | PRO PhosphoSitePlus UniProt | 17425515, 19011241 | ||
| K285 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K299 | Acetylation | score4 | PRO PhosphoSitePlus UniProt | 17425515, 19011241 | ||
| K300 | Acetylation | score4 | PRO PhosphoSitePlus UniProt | 17425515, 19011241 | ||
| K300 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K307 | Acetylation | score4 | PRO PhosphoSitePlus UniProt | 17425515, 19011241 | ||
| S308 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N354 | N-Glycosylation | score2 | GlyGen | 10887202 | ||
| S498 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 11860271, 24305806, 15886016, ... | ||
| S498 | Phosphorylation | O75116 (ROCK2) | score2 | PhosphoSitePlus | 24305806 | |
| S498 | Phosphorylation | P48729 (CSNK1A1) | score2 | PhosphoSitePlus | 11860271 | |
| S498 | Phosphorylation | P48730 (CSNK1D) | score3 | PhosphoSitePlus Signor | 11278841 | |
| K501 | Ubiquitination | score4 | PhosphoSitePlus UniProt | 20484053, 27302062 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S498 | Phosphorylation | score1 | HPRD | 11278841 | ||
| S498 | Phosphorylation | P48730 (CSNK1D) | score1 | HPRD | 11278841 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S473 | Phosphorylation | score1 | HPRD | 11278841 | ||
| S473 | Phosphorylation | P48730 (CSNK1D) | score1 | HPRD | 11278841 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000046454 (hBACE1/SigPep-/Ac:1) | acK126,acK275,acK279,acK285,acK299,acK300,acK307 | PRO |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P56817 (BACE1) | S498 | Q9UJY5 (GGA1) | unknown | eFIP | 22621900 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S71 | L71 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
| S83 | N83 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| K299 | N299 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |
