Protein Information

Cytoscape View


UniProt AC / UniProt ID P56817 / BACE1_HUMAN
Protein Name Beta-secretase 1 precursor
Gene Name Name: BACE1
Synonyms:BACE,KIAA1149;
Organism Homo sapiens (Human)

PRO ID PR:P56817
DAG View
PRO Name beta-secretase 1 (human)
Definition A beta-secretase 1 that is encoded in the genome of human.
Short Label hBACE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P56817 (BACE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T47 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K126 Acetylation PRO   PhosphoSitePlus   UniProt 17425515, 19011241
K136 Acetylation PhosphoSitePlus
T252 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P 26317805
Y260 Phosphorylation PhosphoSitePlus
K275 Acetylation PRO   PhosphoSitePlus   UniProt 17425515, 19011241
K279 Acetylation PRO   PhosphoSitePlus   UniProt 17425515, 19011241
K285 Acetylation PRO   PhosphoSitePlus   UniProt 17425515, 19011241
K285 Ubiquitination PhosphoSitePlus
K299 Acetylation PRO   PhosphoSitePlus   UniProt 17425515, 19011241
K300 Acetylation PRO   PhosphoSitePlus   UniProt 17425515, 19011241
K300 Ubiquitination PhosphoSitePlus
K307 Acetylation PRO   PhosphoSitePlus   UniProt 17425515, 19011241
S308 Phosphorylation PhosphoSitePlus
S498 Phosphorylation O75116 (ROCK2) , P48730 (CSNK1D) , P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11860271, 24305806, 15886016, ...22621900, 28946017, 11278841
K501 Ubiquitination PhosphoSitePlus   UniProt 20484053, 27302062
Site PTM Type PTM Enzyme Score Source PMID
S498 Phosphorylation P48730 (CSNK1D) HPRD 11278841
Site PTM Type PTM Enzyme Score Source PMID
S473 Phosphorylation P48730 (CSNK1D) HPRD 11278841
Site PTM Type PTM Enzyme Score Source PMID
S454 Phosphorylation P48730 (CSNK1D) HPRD 11278841
Site PTM Type PTM Enzyme Score Source PMID
S429 Phosphorylation P48730 (CSNK1D) HPRD 11278841


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046454 (hBACE1/SigPep-/Ac:1) acK126,acK275,acK279,acK285,acK299,acK300,acK307 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P56817 (BACE1) S498 Q9UJY5 (GGA1) unknown eFIP 22621900