iPTMnet Report for P56747 (CLDN6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P56747 / CLD6_HUMAN
Protein Name Claudin-6
Gene Name Name: CLDN6
ORFNames:UNQ757/PRO1488;
Organism Homo sapiens (Human)

PRO ID PR:P56747
DAG View
PRO Name claudin-6 (human)
Definition A claudin-6 that is encoded in the genome of human.
Short Label hCLDN6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P56747 (CLDN6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y196 Phosphorylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
S201 O-Glycosylation GlyGen 25813380
S201 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 19664995
T202 O-Glycosylation GlyGen 25813380
T202 Phosphorylation HPRD   PhosphoSitePlus 19664995
S203 O-Glycosylation GlyGen 25813380
S203 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 19664995
S208 O-Glycosylation GlyGen 25813380
S208 Phosphorylation PhosphoSitePlus   UniProt 21406692
S212 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y214 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
T216 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
Y219 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y196 C196 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S201 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S203 T203 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S212 F212 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K217 N217 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]