iPTMnet Report for P56537 (EIF6)
Protein Information
UniProt AC / UniProt ID | P56537 / IF6_HUMAN |
Protein Name | Eukaryotic translation initiation factor 6 |
Gene Name | Name: EIF6 Synonyms:EIF3A,ITGB4BP;ORFNames:OK/SW-cl.27; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P56537 |
PRO Name | eukaryotic translation initiation factor 6 (human) |
Definition | A eukaryotic translation initiation factor 6 that is encoded in the genome of human. |
Short Label | hEIF6 |
Category | organism-gene |
P56537 (EIF6) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S6 | Phosphorylation | score1 | PhosphoSitePlus | |||
C11 | S-Nitrosylation | score0 | dbSNO | 22178444 | ||
C15 | S-Nitrosylation | score0 | dbSNO | 22178444 | ||
C56 | Methylation | score1 | IEDB | 31844290 | ||
R85 | Methylation | score1 | PhosphoSitePlus | |||
R95 | Methylation | score1 | PhosphoSitePlus | |||
Y113 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 15592455 | ||
S150 | Phosphorylation | score1 | PhosphoSitePlus | |||
S174 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 12917340, 21084295 | ||
S174 | Phosphorylation | P48729 (CSNK1A1) | score2 | PhosphoSitePlus | 21084295 | |
S175 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 12917340, 21084295 | ||
S175 | Phosphorylation | P48729 (CSNK1A1) | score2 | PhosphoSitePlus | 21084295 | |
T185 | Phosphorylation | score1 | PhosphoSitePlus | |||
K223 | Acetylation | score1 | PhosphoSitePlus | |||
S230 | O-Glycosylation | score1 | GlyGen | 23301498, 35008409, 33214551, ... | ||
S230 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
T231 | O-Glycosylation | score1 | GlyGen | 31373491 | ||
T231 | Phosphorylation | score1 | PhosphoSitePlus | |||
T234 | O-Glycosylation | score1 | GlyGen | 31373491 | ||
T234 | Phosphorylation | score1 | PhosphoSitePlus | |||
S235 | O-Glycosylation | score1 | GlyGen | 31373491 | ||
S235 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 14654845, 18669648, 21665150 | ||
S235 | Phosphorylation | P05771 (PRKCB) | score4 | neXtProt Signor | 14654845, 21665150 | |
S235 | Phosphorylation | P17252 (PRKCA) | score3 | PhosphoSitePlus Signor | 14654845 | |
S239 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
S243 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
T245 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y113 | Phosphorylation | score0 | HPRD | 15592455 | ||
S175 | Phosphorylation | score0 | HPRD | 18452278 | ||
S230 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
T234 | Phosphorylation | score1 | HPRD | 14654845 | ||
T234 | Phosphorylation | P05771 (PRKCB) | score1 | HPRD | 14654845 | |
S235 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
S239 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
S243 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
T245 | Phosphorylation | score0 | HPRD | 19007248 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S40 | Phosphorylation | score1 | PhosphoSitePlus | |||
K54 | Ubiquitination | score1 | PhosphoSitePlus | |||
S156 | Phosphorylation | score0 | HPRD | 18452278 | ||
S211 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
T215 | Phosphorylation | score1 | HPRD | 14654845 | ||
T215 | Phosphorylation | P05771 (PRKCB) | score1 | HPRD | 14654845 | |
S216 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
S220 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
S224 | Phosphorylation | score0 | HPRD | 18669648, 19007248, 20068231 | ||
T226 | Phosphorylation | score0 | HPRD | 19007248 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S6 | L6 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S40 | G40 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
K54 | T54 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
R85 | H85 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
S156 | F156 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S175 | F175 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T185 | S185 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
T185 | I185 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |