Protein Information

Cytoscape View


UniProt AC / UniProt ID P56537 / IF6_HUMAN
Protein Name Eukaryotic translation initiation factor 6
Gene Name Name: EIF6
Synonyms:EIF3A,ITGB4BP;ORFNames:OK/SW-cl.27;
Organism Homo sapiens (Human)

PRO ID PR:P56537
DAG View
PRO Name eukaryotic translation initiation factor 6 (human)
Definition A eukaryotic translation initiation factor 6 that is encoded in the genome of human.
Short Label hEIF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P56537 (EIF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
C11 S-Nitrosylation dbSNO 22178444
C15 S-Nitrosylation dbSNO 22178444
R85 Methylation PhosphoSitePlus
R95 Methylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus   UniProt 15592455
S150 Phosphorylation PhosphoSitePlus
S174 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus   RLIMS-P   UniProt 12917340, 21084295
S175 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus   RLIMS-P   UniProt 12917340, 21084295
T185 Phosphorylation PhosphoSitePlus
K223 Acetylation PhosphoSitePlus
S230 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T231 Phosphorylation PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
S235 Phosphorylation P17252 (PRKCA) , P05771 (PRKCB) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14654845, 18669648, 21536732, ...21665150
S239 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S243 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T245 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y113 Phosphorylation HPRD 15592455
S175 Phosphorylation HPRD 18452278
S230 Phosphorylation HPRD 18669648, 20068231
T234 Phosphorylation P05771 (PRKCB) HPRD 14654845
S235 Phosphorylation HPRD 18669648, 19007248, 20068231
S239 Phosphorylation HPRD 18669648, 19007248, 20068231
S243 Phosphorylation HPRD 18669648, 19007248, 20068231
T245 Phosphorylation HPRD 19007248
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S156 Phosphorylation HPRD 18452278
S211 Phosphorylation HPRD 18669648, 20068231
T215 Phosphorylation P05771 (PRKCB) HPRD 14654845
S216 Phosphorylation HPRD 18669648, 19007248, 20068231
S220 Phosphorylation HPRD 18669648, 19007248, 20068231
S224 Phosphorylation HPRD 18669648, 19007248, 20068231
T226 Phosphorylation HPRD 19007248


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R85 H85 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]