iPTMnet Report for P55211 (CASP9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P55211 / CASP9_HUMAN
Protein Name Caspase-9 precursor
Gene Name Name: CASP9
Synonyms:MCH6;
Organism Homo sapiens (Human)

PRO ID PR:P55211
DAG View
PRO Name caspase-9 (human)
Definition A caspase-9 that is encoded in the genome of human.
Short Label hCASP9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P55211 (CASP9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K97 Ubiquitination PhosphoSitePlus
S99 Phosphorylation neXtProt   PhosphoSitePlus   Signor 15703181
S99 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 15703181
K100 Ubiquitination PhosphoSitePlus
T107 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
T125 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21219631, 16287866, 19016842, ...21637382, 16888006, 19586613, 18083711, 27580936, 18669648, 19081073, 17466630, 17504303, 12792650, 29416675
T125 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 16287866, 17466630
T125 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   Signor 12792650, 18083711
T125 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12792650, 18083711
T125 Phosphorylation Q13627 (DYRK1A) neXtProt 19081073, 19016842, 19586613
S133 Phosphorylation PhosphoSitePlus
S144 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16287866
S144 Phosphorylation Q05513 (PRKCZ) neXtProt   PhosphoSitePlus   Signor 16287866
Y153 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15657060, 29066624
Y153 Phosphorylation A0A173G4P4 (Abl fusion) phospho.ELM 15657060
Y153 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor 15657060
S175 Phosphorylation PhosphoSitePlus
S183 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 29352269, 15703181
S183 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 15703181
K189 Ubiquitination PhosphoSitePlus
S195 Phosphorylation neXtProt   PhosphoSitePlus   Signor 15703181
S195 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 15703181
S196 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 18551195, 19909554, 18840507, ...21078168, 9812896, 10529400, 20494139, 15004527
S196 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 9812896, 15004527, 10529400
S196 Phosphorylation P31751 (AKT2) Signor 9812896, 15004527
S196 Phosphorylation Q13237 (PRKG2) neXtProt 18551195
S196 Phosphorylation Q9Y243 (AKT3) Signor 9812896
K204 Ubiquitination PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus   RLIMS-P 29844931
K278 Ubiquitination PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
S302 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S307 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S310 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K394 Ubiquitination PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus   RLIMS-P 29066624
Site PTM Type PTM Enzyme Score Source PMID
T125 Phosphorylation HPRD 12792650, 18669648
T125 Phosphorylation P27361 (MAPK3) HPRD 12792650, 18669648
T125 Phosphorylation P28482 (MAPK1) HPRD 12792650, 18669648
T125 Phosphorylation P36507 (MAP2K2) HPRD 12792650, 18669648
T125 Phosphorylation Q02750 (MAP2K1) HPRD 12792650, 18669648
S144 Phosphorylation HPRD 16287866
S144 Phosphorylation Q05513 (PRKCZ) HPRD 16287866
Y153 Phosphorylation HPRD 15657060
Y153 Phosphorylation P00519 (ABL1) HPRD 15657060
S183 Phosphorylation HPRD 9812896
S183 Phosphorylation P31749 (AKT1) HPRD 9812896
S196 Phosphorylation HPRD 9812896
S196 Phosphorylation P31749 (AKT1) HPRD 9812896
S302 Phosphorylation HPRD 18669648
S307 Phosphorylation HPRD 18669648, 20068231
S310 Phosphorylation HPRD 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046571 (hCASP9/Phos:2) pS196 PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q96CA5-2 (hBIRC7/iso:1) Interaction PR:P55211 (hCASP9) PRO 11084335


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S99 L99 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T107 A107 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T125 P125 Biomuta DOID:4159 / skin cancer [ cosmic ]
S133 F133 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S183 F183 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y251 C251 Biomuta [ cosmic ]
K278 R278 Biomuta DOID:1324 / lung cancer [ cosmic ]
K278 N278 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S302 F302 Biomuta DOID:4159 / skin cancer [ cosmic ]
S307 F307 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S310 I310 Biomuta DOID:1324 / lung cancer [ cosmic ]