Protein Information

Cytoscape View


UniProt AC / UniProt ID P55087 / AQP4_HUMAN
Protein Name Aquaporin-4
Gene Name Name: AQP4
Organism Homo sapiens (Human)

PRO ID PR:P55087
DAG View
PRO Name aquaporin-4 (human)
Definition An aquaporin-4 that is encoded in the genome of human.
Short Label hAQP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P55087 (AQP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S111 Phosphorylation PhosphoSitePlus   RLIMS-P 19850109
S180 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   RLIMS-P 19761816, 19850109
S276 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P 26013827, 11742978
Y277 Phosphorylation PhosphoSitePlus
S285 Phosphorylation phospho.ELM   PhosphoSitePlus 11742978
T289 Phosphorylation PhosphoSitePlus
K295 Methylation PhosphoSitePlus
S316 Phosphorylation phospho.ELM 11742978
S321 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S276 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD 11742978
S285 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD 11742978
S316 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD 11742978
Site PTM Type PTM Enzyme Score Source PMID
S254 Phosphorylation P68400 (CSNK2A1) HPRD 11742978
S263 Phosphorylation P68400 (CSNK2A1) HPRD 11742978
S294 Phosphorylation P68400 (CSNK2A1) HPRD 11742978


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S276 N276 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T289 M289 Biomuta DOID:1909 / melanoma [ cosmic ]
T289 K289 Biomuta DOID:3571 / liver cancer [ icgc ]
S316 F316 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S321 Y321 Biomuta DOID:3070 / malignant glioma [ tcga ]
S322 L322 Biomuta DOID:1909 / melanoma [ tcga ]