iPTMnet Report P55087 AQP4

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P55087 / AQP4_HUMAN
Protein Name	Aquaporin-4
Gene Name	Name: AQP4
Organism	Homo sapiens (Human)

PRO ID	PR:P55087 DAG View
PRO Name	aquaporin-4 (human)
Definition	An aquaporin-4 that is encoded in the genome of human.
Short Label	hAQP4
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P55087 (AQP4) as Substrate

Expanded View

Search:

	Site Select all By amino acid All Serine All Threonine All Tyrosine By position S111 S180 S276 Y277 S285 T289 K295 S316 S321 S322	PTM Type Select all Methylation Phosphorylation	PTM Enzyme	Score Select all 1 2 3 4	Source Select all PhosphoSitePlus RLIMS-P phospho.ELM	PMID
	S111	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	19850109
	S180	Phosphorylation	P17252 (PRKCA)	score4	PhosphoSitePlus RLIMS-P	19761816, 19850109
	S276	Phosphorylation	P17612 (PRKACA)	score4	phospho.ELM PhosphoSitePlus RLIMS-P	11742978, 32413299, 26013827
	Y277	Phosphorylation		score1	PhosphoSitePlus
	S285	Phosphorylation		score3	phospho.ELM PhosphoSitePlus	11742978
	T289	Phosphorylation		score1	PhosphoSitePlus
	K295	Methylation		score1	PhosphoSitePlus
	S316	Phosphorylation		score2	phospho.ELM	11742978
	S321	Phosphorylation		score1	PhosphoSitePlus
	S322	Phosphorylation		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid All Serine By position S276 S285 S316	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all HPRD	PMID
	S276	Phosphorylation	P19784 (CSNK2A2) , P68400 (CSNK2A1)	score1	HPRD	11742978
	S285	Phosphorylation	P68400 (CSNK2A1) , P19784 (CSNK2A2)	score1	HPRD	11742978
	S316	Phosphorylation	P19784 (CSNK2A2) , P68400 (CSNK2A1)	score1	HPRD	11742978

Search:

	Site Select all By amino acid All Serine By position S254 S263 S294	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all HPRD	PMID
	S254	Phosphorylation	P68400 (CSNK2A1)	score1	HPRD	11742978
	S263	Phosphorylation	P68400 (CSNK2A1)	score1	HPRD	11742978
	S294	Phosphorylation	P68400 (CSNK2A1)	score1	HPRD	11742978

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine By position S263 S294	Variant Select all F294 I263	Source Select all Biomuta	PMID	Disease [Sample source] Select all DOID:1324 / lung cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S263	I263	Biomuta		DOID:1324 / lung cancer [ cosmic ]
S294	F294	Biomuta		DOID:1612 / breast cancer [ cosmic, icgc ]