iPTMnet Report for P52888 (THOP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52888 / THOP1_HUMAN
Protein Name Thimet oligopeptidase
Gene Name Name: THOP1
Organism Homo sapiens (Human)

PRO ID PR:P52888
DAG View
PRO Name thimet oligopeptidase (human)
Definition A thimet oligopeptidase that is encoded in the genome of human.
Short Label hTHOP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52888 (THOP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus   UniProt 23186163
C18 Methylation IEDB 31844290
S19 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
K239 Acetylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K249 Acetylation PhosphoSitePlus
K257 Acetylation PhosphoSitePlus   UniProt 19608861
K257 Ubiquitination PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
T287 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
Y412 Phosphorylation PhosphoSitePlus
Y416 Phosphorylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
Y422 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
K538 Acetylation PhosphoSitePlus   UniProt 19608861
K538 Ubiquitination PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
C580 Methylation IEDB 31844290
K628 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
Y641 Phosphorylation PhosphoSitePlus
S643 Phosphorylation phospho.ELM   PhosphoSitePlus 10969067
K667 Ubiquitination PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
C682 S-Nitrosylation dbSNO 26338901, 22126794
C689 S-Nitrosylation dbSNO 26338901, 22126794
Site PTM Type PTM Enzyme Score Source PMID
T347 Phosphorylation HPRD 20068231
Y412 Phosphorylation HPRD 20068231
Y416 Phosphorylation HPRD 20068231
Y422 Phosphorylation HPRD 20068231
S643 Phosphorylation P17612 (PRKACA) HPRD 10969067


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 F16 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S16 Y16 Biomuta DOID:363 / uterine cancer [ icgc ]
S19 F19 Biomuta DOID:4159 / skin cancer [ cosmic ]
S89 F89 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K128 N128 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K216 T216 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y221 C221 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y278 C278 Biomuta DOID:3571 / liver cancer [ cosmic ]
K636 N636 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S643 G643 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]