iPTMnet Report for P52888 (THOP1)
Protein Information
UniProt AC / UniProt ID | P52888 / THOP1_HUMAN |
Protein Name | Thimet oligopeptidase |
Gene Name | Name: THOP1 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P52888 |
PRO Name | thimet oligopeptidase (human) |
Definition | A thimet oligopeptidase that is encoded in the genome of human. |
Short Label | hTHOP1 |
Category | organism-gene |
P52888 (THOP1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S16 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
C18 | Methylation | score1 | IEDB | 31844290 | ||
S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
K45 | Ubiquitination | score1 | PhosphoSitePlus | |||
S89 | Phosphorylation | score1 | PhosphoSitePlus | |||
K92 | Acetylation | score1 | PhosphoSitePlus | |||
K92 | Ubiquitination | score1 | PhosphoSitePlus | |||
T99 | Phosphorylation | score1 | PhosphoSitePlus | |||
K128 | Ubiquitination | score1 | PhosphoSitePlus | |||
K131 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y141 | Phosphorylation | score1 | PhosphoSitePlus | |||
K170 | Ubiquitination | score1 | PhosphoSitePlus | |||
K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
K220 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y221 | Phosphorylation | score1 | PhosphoSitePlus | |||
K239 | Acetylation | score1 | PhosphoSitePlus | |||
K239 | Ubiquitination | score1 | PhosphoSitePlus | |||
K249 | Acetylation | score1 | PhosphoSitePlus | |||
K257 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K257 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y278 | Phosphorylation | score1 | PhosphoSitePlus | |||
T287 | Phosphorylation | score1 | PhosphoSitePlus | |||
K303 | Ubiquitination | score1 | PhosphoSitePlus | |||
K317 | Ubiquitination | score1 | PhosphoSitePlus | |||
T347 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y412 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y416 | Phosphorylation | score1 | PhosphoSitePlus | |||
K421 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y422 | Phosphorylation | score1 | PhosphoSitePlus | |||
S529 | Phosphorylation | score1 | PhosphoSitePlus | |||
K538 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K538 | Ubiquitination | score1 | PhosphoSitePlus | |||
K559 | Ubiquitination | score1 | PhosphoSitePlus | |||
C580 | Methylation | score1 | IEDB | 31844290 | ||
K628 | Ubiquitination | score1 | PhosphoSitePlus | |||
K636 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y641 | Phosphorylation | score1 | PhosphoSitePlus | |||
S643 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 10969067 | ||
K667 | Ubiquitination | score1 | PhosphoSitePlus | |||
K675 | Ubiquitination | score1 | PhosphoSitePlus | |||
C682 | S-Nitrosylation | score0 | dbSNO | 26338901, 22126794 | ||
C689 | S-Nitrosylation | score0 | dbSNO | 26338901, 22126794 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T347 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y412 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y416 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y422 | Phosphorylation | score0 | HPRD | 20068231 | ||
S643 | Phosphorylation | score1 | HPRD | 10969067 | ||
S643 | Phosphorylation | P17612 (PRKACA) | score1 | HPRD | 10969067 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S16 | F16 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S16 | Y16 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S19 | F19 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S89 | F89 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
K128 | N128 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K216 | T216 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
Y221 | C221 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
Y278 | C278 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
K636 | N636 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S643 | G643 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |