iPTMnet Report for P52655 (GTF2A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52655 / TF2AA_HUMAN
Protein Name Transcription initiation factor IIA subunit 1
Gene Name Name: GTF2A1
Synonyms:TF2A1;
Organism Homo sapiens (Human)

PRO ID PR:P52655
DAG View
PRO Name transcription initiation factor IIA subunit 1 (human)
Definition A transcription initiation factor IIA subunit 1 that is encoded in the genome of human.
Short Label hGTF2A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52655 (GTF2A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
T9 Phosphorylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
R167 Methylation PhosphoSitePlus
T229 O-Glycosylation GlyGen 23301498, 34019948, 29351928
T238 O-Glycosylation GlyGen 23301498, 34019948, 29351928
T239 O-Glycosylation GlyGen 23301498, 34019948, 29351928
T244 O-Glycosylation GlyGen 23301498, 34019948, 29351928
T251 O-Glycosylation GlyGen 23301498, 34019948, 29351928
T253 O-Glycosylation GlyGen 23301498, 34019948, 29351928
T265 O-Glycosylation GlyGen 23301498, 34019948, 29351928
S280 Phosphorylation P21675 (TAF1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11278496
S281 Phosphorylation P21675 (TAF1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11278496
S316 Phosphorylation P21675 (TAF1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11278496, 17081983
S321 Phosphorylation P21675 (TAF1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11278496, 17081983
C337 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S280 Phosphorylation P21675 (TAF1) , P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD 11278496
S281 Phosphorylation P21675 (TAF1) , P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD 11278496
S316 Phosphorylation P21675 (TAF1) , P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD 11278496, 18452278
S321 Phosphorylation P68400 (CSNK2A1) , P21675 (TAF1) , P19784 (CSNK2A2) HPRD 11278496, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S241 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) , P21675 (TAF1) HPRD 11278496
S242 Phosphorylation P21675 (TAF1) , P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD 11278496
S277 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) , P21675 (TAF1) HPRD 11278496, 18452278
S282 Phosphorylation P19784 (CSNK2A2) , P21675 (TAF1) , P68400 (CSNK2A1) HPRD 11278496, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T9 P9 Biomuta DOID:1324 / lung cancer [ cosmic ]
S16 Y16 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T238 M238 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T239 I239 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S282 N282 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S282 R282 Biomuta DOID:1324 / lung cancer [ cosmic ]
S321 R321 Biomuta DOID:1324 / lung cancer [ cosmic ]
S321 N321 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]