iPTMnet Report for P52655 (GTF2A1)
Protein Information
| UniProt AC / UniProt ID | P52655 / TF2AA_HUMAN |
| Protein Name | Transcription initiation factor IIA subunit 1 |
| Gene Name | Name: GTF2A1 Synonyms:TF2A1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P52655 |
| PRO Name | transcription initiation factor IIA subunit 1 (human) |
| Definition | A transcription initiation factor IIA subunit 1 that is encoded in the genome of human. |
| Short Label | hGTF2A1 |
| Category | organism-gene |
DAG ViewP52655 (GTF2A1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| A2 | Acetylation | score1 | UniProt | 19413330, 22814378 | ||
| T9 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K12 | Acetylation | score1 | PhosphoSitePlus | |||
| S16 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K49 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R167 | Methylation | score1 | PhosphoSitePlus | |||
| T229 | O-Glycosylation | score1 | GlyGen | 23301498, 34019948, 29351928 | ||
| T238 | O-Glycosylation | score1 | GlyGen | 23301498, 34019948, 29351928 | ||
| T239 | O-Glycosylation | score1 | GlyGen | 23301498, 34019948, 29351928 | ||
| T244 | O-Glycosylation | score1 | GlyGen | 23301498, 34019948, 29351928 | ||
| T251 | O-Glycosylation | score1 | GlyGen | 23301498, 34019948, 29351928 | ||
| T253 | O-Glycosylation | score1 | GlyGen | 23301498, 34019948, 29351928 | ||
| T265 | O-Glycosylation | score1 | GlyGen | 23301498, 34019948, 29351928 | ||
| S280 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus Signor UniProt | 11278496 | ||
| S280 | Phosphorylation | P21675 (TAF1) | score1 | Signor | 11278496 | |
| S281 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus Signor UniProt | 11278496 | ||
| S281 | Phosphorylation | P21675 (TAF1) | score1 | Signor | 11278496 | |
| S316 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 11278496, 17081983 | ||
| S316 | Phosphorylation | P21675 (TAF1) | score3 | PhosphoSitePlus Signor | 11278496 | |
| S321 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 11278496, 17081983 | ||
| S321 | Phosphorylation | P21675 (TAF1) | score3 | PhosphoSitePlus Signor | 11278496 | |
| C337 | Methylation | score1 | IEDB | 31844290 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S280 | Phosphorylation | score1 | HPRD | 11278496 | ||
| S280 | Phosphorylation | P19784 (CSNK2A2) | score1 | HPRD | 11278496 | |
| S280 | Phosphorylation | P21675 (TAF1) | score1 | HPRD | 11278496 | |
| S280 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 11278496 | |
| S281 | Phosphorylation | score1 | HPRD | 11278496 | ||
| S281 | Phosphorylation | P19784 (CSNK2A2) | score1 | HPRD | 11278496 | |
| S281 | Phosphorylation | P21675 (TAF1) | score1 | HPRD | 11278496 | |
| S281 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 11278496 | |
| S316 | Phosphorylation | score2 | HPRD | 11278496, 18452278 | ||
| S316 | Phosphorylation | P19784 (CSNK2A2) | score2 | HPRD | 11278496, 18452278 | |
| S316 | Phosphorylation | P21675 (TAF1) | score2 | HPRD | 11278496, 18452278 | |
| S316 | Phosphorylation | P68400 (CSNK2A1) | score2 | HPRD | 11278496, 18452278 | |
| S321 | Phosphorylation | score2 | HPRD | 11278496, 18452278 | ||
| S321 | Phosphorylation | P19784 (CSNK2A2) | score2 | HPRD | 11278496, 18452278 | |
| S321 | Phosphorylation | P21675 (TAF1) | score2 | HPRD | 11278496, 18452278 | |
| S321 | Phosphorylation | P68400 (CSNK2A1) | score2 | HPRD | 11278496, 18452278 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S241 | Phosphorylation | score1 | HPRD | 11278496 | ||
| S241 | Phosphorylation | P19784 (CSNK2A2) | score1 | HPRD | 11278496 | |
| S241 | Phosphorylation | P21675 (TAF1) | score1 | HPRD | 11278496 | |
| S241 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 11278496 | |
| S242 | Phosphorylation | score1 | HPRD | 11278496 | ||
| S242 | Phosphorylation | P19784 (CSNK2A2) | score1 | HPRD | 11278496 | |
| S242 | Phosphorylation | P21675 (TAF1) | score1 | HPRD | 11278496 | |
| S242 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 11278496 | |
| S277 | Phosphorylation | score2 | HPRD | 11278496, 18452278 | ||
| S277 | Phosphorylation | P19784 (CSNK2A2) | score2 | HPRD | 11278496, 18452278 | |
| S277 | Phosphorylation | P21675 (TAF1) | score2 | HPRD | 11278496, 18452278 | |
| S277 | Phosphorylation | P68400 (CSNK2A1) | score2 | HPRD | 11278496, 18452278 | |
| S282 | Phosphorylation | score2 | HPRD | 11278496, 18452278 | ||
| S282 | Phosphorylation | P19784 (CSNK2A2) | score2 | HPRD | 11278496, 18452278 | |
| S282 | Phosphorylation | P21675 (TAF1) | score2 | HPRD | 11278496, 18452278 | |
| S282 | Phosphorylation | P68400 (CSNK2A1) | score2 | HPRD | 11278496, 18452278 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T9 | P9 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S16 | Y16 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| T238 | M238 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| T239 | I239 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S282 | N282 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S282 | R282 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S321 | R321 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S321 | N321 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] |
