iPTMnet Report for P52630 (STAT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52630 / STAT2_HUMAN
Protein Name Signal transducer and activator of transcription 2
Gene Name Name: STAT2
Organism Homo sapiens (Human)

PRO ID PR:P52630
DAG View
PRO Name signal transducer and activator of transcription 2 (human)
Definition A signal transducer and activator of transcription 2 that is encoded in the genome of human.
Short Label hSTAT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52630 (STAT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
K158 Acetylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus   UniProt 23139419
S287 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27802159, 23139419
T294 Phosphorylation PhosphoSitePlus   UniProt 23139419
K295 Ubiquitination PhosphoSitePlus
C323 Methylation IEDB 31844290
S338 O-Glycosylation GlyGen 29351928
T341 O-Glycosylation GlyGen 29351928
K375 Acetylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
K384 Acetylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
T385 Phosphorylation PhosphoSitePlus
T387 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
T404 Phosphorylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
T597 Phosphorylation PhosphoSitePlus
Y631 Phosphorylation PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
Y690 Phosphorylation P06239 (LCK) IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 8605877, 7532278, 25564224, ...32778820, 22704065, 16324217, 36148221, 32696599, 22306001, 9121453, 26342467, 29317535, 8197134, 32196427, 29581268
S699 Phosphorylation PhosphoSitePlus
S734 Phosphorylation PhosphoSitePlus   RLIMS-P 27802159
S753 Phosphorylation PhosphoSitePlus   UniProt 24275569
T800 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y833 Phosphorylation PhosphoSitePlus
S849 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K182 Acetylation PR:Q92793 (hCREBBP) PRO 17923090
K184 Acetylation PR:Q92793 (hCREBBP) PRO 17923090
K194 Acetylation PR:Q92793 (hCREBBP) PRO 17923090
K197 Acetylation PR:Q92793 (hCREBBP) PRO 17923090
K384 Acetylation PR:Q92793 (hCREBBP) PRO 17923090
K390 Acetylation PR:Q92793 (hCREBBP) PRO 17923090
K415 Acetylation PR:Q92793 (hCREBBP) PRO 17923090
K419 Acetylation PR:Q92793 (hCREBBP) PRO 17923090
T542 Phosphorylation HPRD 20068231
K592 Acetylation PR:Q92793 (hCREBBP) PRO 17923090
Y690 Phosphorylation P23458 (JAK1) HPRD 9020188


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049365 (hSTAT2/Phos:1) pY690 PRO
PR:000028654 (hSTAT2/iso:1/Ac:1) acK182,acK184,acK194,acK197,acK384,acK390,acK415,acK419,acK592 PR:Q92793 (hCREBBP) PRO 17923090


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P42224 (STAT1) S727 P52630 (STAT2) unknown eFIP 18574148


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K161 E161 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K197 T197 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S287 G287 Biomuta DOID:363 / uterine cancer [ icgc ]
S381 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T542 S542 Biomuta DOID:1612 / breast cancer [ cosmic ]
S753 F753 Biomuta DOID:363 / uterine cancer [ icgc ]