iPTMnet Report for P52630 (STAT2)
Protein Information
UniProt AC / UniProt ID | P52630 / STAT2_HUMAN |
Protein Name | Signal transducer and activator of transcription 2 |
Gene Name | Name: STAT2 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P52630 |
PRO Name | signal transducer and activator of transcription 2 (human) |
Definition | A signal transducer and activator of transcription 2 that is encoded in the genome of human. |
Short Label | hSTAT2 |
Category | organism-gene |
P52630 (STAT2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S12 | Phosphorylation | score1 | PhosphoSitePlus | |||
T136 | Phosphorylation | score1 | PhosphoSitePlus | |||
K158 | Acetylation | score1 | PhosphoSitePlus | |||
K158 | Ubiquitination | score1 | PhosphoSitePlus | |||
K161 | Ubiquitination | score1 | PhosphoSitePlus | |||
K167 | Ubiquitination | score1 | PhosphoSitePlus | |||
K184 | Ubiquitination | score1 | PhosphoSitePlus | |||
S187 | Phosphorylation | score1 | PhosphoSitePlus | |||
K194 | Ubiquitination | score1 | PhosphoSitePlus | |||
K197 | Ubiquitination | score1 | PhosphoSitePlus | |||
K208 | Ubiquitination | score1 | PhosphoSitePlus | |||
K218 | Ubiquitination | score1 | PhosphoSitePlus | |||
K239 | Ubiquitination | score1 | PhosphoSitePlus | |||
K244 | Ubiquitination | score1 | PhosphoSitePlus | |||
K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
S283 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 23139419 | ||
S287 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 27802159, 23139419 | ||
T294 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 23139419 | ||
K295 | Ubiquitination | score1 | PhosphoSitePlus | |||
C323 | Methylation | score1 | IEDB | 31844290 | ||
S338 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
T341 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
K375 | Acetylation | score1 | PhosphoSitePlus | |||
K375 | Ubiquitination | score1 | PhosphoSitePlus | |||
S381 | Phosphorylation | score1 | PhosphoSitePlus | |||
K384 | Acetylation | score1 | PhosphoSitePlus | |||
K384 | Ubiquitination | score1 | PhosphoSitePlus | |||
T385 | Phosphorylation | score1 | PhosphoSitePlus | |||
T387 | Phosphorylation | score1 | PhosphoSitePlus | |||
S393 | Phosphorylation | score1 | PhosphoSitePlus | |||
T404 | Phosphorylation | score1 | PhosphoSitePlus | |||
K443 | Ubiquitination | score1 | PhosphoSitePlus | |||
K523 | Ubiquitination | score1 | PhosphoSitePlus | |||
K543 | Ubiquitination | score1 | PhosphoSitePlus | |||
K550 | Ubiquitination | score1 | PhosphoSitePlus | |||
S595 | Phosphorylation | score1 | PhosphoSitePlus | |||
T597 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y631 | Phosphorylation | score1 | PhosphoSitePlus | |||
K681 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y690 | Phosphorylation | score4 | IntAct phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt | 8605877, 7532278, 25564224, ... | ||
Y690 | Phosphorylation | P06239 (LCK) | score2 | PhosphoSitePlus | 8197134 | |
S699 | Phosphorylation | score1 | PhosphoSitePlus | |||
S734 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 27802159 | ||
S753 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
T800 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
Y833 | Phosphorylation | score1 | PhosphoSitePlus | |||
S849 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K182 | Acetylation | score2 | PRO | 17923090 | ||
K182 | Acetylation | PR:Q92793 (hCREBBP) | score2 | PRO | 17923090 | |
K184 | Acetylation | score2 | PRO | 17923090 | ||
K184 | Acetylation | PR:Q92793 (hCREBBP) | score2 | PRO | 17923090 | |
K194 | Acetylation | score2 | PRO | 17923090 | ||
K194 | Acetylation | PR:Q92793 (hCREBBP) | score2 | PRO | 17923090 | |
K197 | Acetylation | score2 | PRO | 17923090 | ||
K197 | Acetylation | PR:Q92793 (hCREBBP) | score2 | PRO | 17923090 | |
K384 | Acetylation | score2 | PRO | 17923090 | ||
K384 | Acetylation | PR:Q92793 (hCREBBP) | score2 | PRO | 17923090 | |
K390 | Acetylation | score2 | PRO | 17923090 | ||
K390 | Acetylation | PR:Q92793 (hCREBBP) | score2 | PRO | 17923090 | |
K415 | Acetylation | score2 | PRO | 17923090 | ||
K415 | Acetylation | PR:Q92793 (hCREBBP) | score2 | PRO | 17923090 | |
K419 | Acetylation | score2 | PRO | 17923090 | ||
K419 | Acetylation | PR:Q92793 (hCREBBP) | score2 | PRO | 17923090 | |
T542 | Phosphorylation | score0 | HPRD | 20068231 | ||
K592 | Acetylation | score2 | PRO | 17923090 | ||
K592 | Acetylation | PR:Q92793 (hCREBBP) | score2 | PRO | 17923090 | |
Y690 | Phosphorylation | score1 | HPRD | 9020188 | ||
Y690 | Phosphorylation | P23458 (JAK1) | score1 | HPRD | 9020188 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000049365 (hSTAT2/Phos:1) | pY690 | PRO | |||
PR:000028654 (hSTAT2/iso:1/Ac:1) | acK182,acK184,acK194,acK197,acK384,acK390,acK415,acK419,acK592 | PR:Q92793 (hCREBBP) | PRO | 17923090 |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P42224 (STAT1) | S727 | P52630 (STAT2) | unknown | eFIP | 18574148 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K161 | E161 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K197 | T197 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S287 | G287 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S381 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T542 | S542 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S753 | F753 | Biomuta | DOID:363 / uterine cancer [ icgc ] |