iPTMnet Report for P52434 (POLR2H)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P52434 / RPAB3_HUMAN
Protein Name DNA-directed RNA polymerases I, II, and III subunit RPABC3
Gene Name Name: POLR2H
Organism Homo sapiens (Human)

PRO ID PR:P52434
DAG View
PRO Name DNA-directed RNA polymerases I, II, and III subunit RPABC3 (human)
Definition A DNA-directed RNA polymerases I, II, and III subunit RPABC3 that is encoded in the genome of human.
Short Label hPOLR2H
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P52434 (POLR2H) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
K13 Sumoylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
C30 Methylation IEDB 31844290
K36 Acetylation PhosphoSitePlus
Y65 Phosphorylation PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
T78 Phosphorylation PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K21 T21 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y118 F118 Biomuta DOID:9256 / colorectal cancer [ cosmic ]