iPTMnet Report for P52434 (POLR2H)
Protein Information
UniProt AC / UniProt ID | P52434 / RPAB3_HUMAN |
Protein Name | DNA-directed RNA polymerases I, II, and III subunit RPABC3 |
Gene Name | Name: POLR2H |
Organism | Homo sapiens (Human) |
PRO ID | PR:P52434 |
PRO Name | DNA-directed RNA polymerases I, II, and III subunit RPABC3 (human) |
Definition | A DNA-directed RNA polymerases I, II, and III subunit RPABC3 that is encoded in the genome of human. |
Short Label | hPOLR2H |
Category | organism-gene |
P52434 (POLR2H) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19413330, 22814378, 22223895 | ||
K13 | Sumoylation | score1 | PhosphoSitePlus | |||
K13 | Ubiquitination | score1 | PhosphoSitePlus | |||
K20 | Ubiquitination | score1 | PhosphoSitePlus | |||
K21 | Ubiquitination | score1 | PhosphoSitePlus | |||
C30 | Methylation | score1 | IEDB | 31844290 | ||
K36 | Acetylation | score1 | PhosphoSitePlus | |||
Y65 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y75 | Phosphorylation | score1 | PhosphoSitePlus | |||
T78 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y90 | Phosphorylation | score1 | PhosphoSitePlus | |||
K95 | Ubiquitination | score1 | PhosphoSitePlus | |||
T104 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y118 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y142 | Phosphorylation | score1 | PhosphoSitePlus | |||
K146 | Ubiquitination | score1 | PhosphoSitePlus | |||
K147 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K21 | T21 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
Y118 | F118 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |