iPTMnet Report P51955 NEK2

Protein Information

UniProt AC / UniProt ID	P51955 / NEK2_HUMAN
Protein Name	Serine/threonine-protein kinase Nek2
Gene Name	Name: NEK2 Synonyms:NEK2A,NLK1;
Organism	Homo sapiens (Human)

PRO ID	PR:P51955 DAG View
PRO Name	serine/threonine-protein kinase Nek2 (human)
Definition	A serine/threonine-protein kinase Nek2 that is encoded in the genome of human.
Short Label	hNEK2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P51955 (NEK2) as Substrate

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
K37	Ubiquitination		score1	PhosphoSitePlus
K63	Ubiquitination		score1	PhosphoSitePlus
K143	Ubiquitination		score1	PhosphoSitePlus
K152	Ubiquitination		score1	PhosphoSitePlus
K156	Ubiquitination		score1	PhosphoSitePlus
T170	Phosphorylation		score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
T170	Phosphorylation	P51955 (NEK2)	score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
S171	Phosphorylation		score4	neXtProt PhosphoSitePlus Signor UniProt	23186163, 17197699
S171	Phosphorylation	P51955 (NEK2)	score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
K174	Ubiquitination		score1	PhosphoSitePlus
T175	Phosphorylation		score4	neXtProt PhosphoSitePlus RLIMS-P Signor UniProt	20936789, 17197699
T175	Phosphorylation	P51955 (NEK2)	score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
T179	Phosphorylation		score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
T179	Phosphorylation	P51955 (NEK2)	score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
S184	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	22067460, 23186163
K227	Ubiquitination		score1	PhosphoSitePlus
S241	Phosphorylation		score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
S241	Phosphorylation	P51955 (NEK2)	score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
S261	Phosphorylation		score1	PhosphoSitePlus
K295	Ubiquitination		score1	PhosphoSitePlus
S296	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976, 19369195
S300	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S304	Phosphorylation		score1	PhosphoSitePlus
K307	Ubiquitination		score1	PhosphoSitePlus
K309	Ubiquitination		score1	PhosphoSitePlus
K330	Ubiquitination		score1	PhosphoSitePlus
K344	Ubiquitination		score1	PhosphoSitePlus
K353	Ubiquitination		score1	PhosphoSitePlus
S356	Phosphorylation		score4	neXtProt PhosphoSitePlus UniProt	21076410, 17197699
S356	Phosphorylation	P51955 (NEK2)	score3	neXtProt PhosphoSitePlus	17197699
S356	Phosphorylation	Q13188 (STK3)	score3	neXtProt PhosphoSitePlus	21076410
K359	Ubiquitination		score1	PhosphoSitePlus
K362	Ubiquitination		score1	PhosphoSitePlus
S365	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	21076410, 22067460
S365	Phosphorylation	Q13188 (STK3)	score3	neXtProt PhosphoSitePlus	21076410
S378	Phosphorylation		score1	PhosphoSitePlus
K381	Ubiquitination		score1	PhosphoSitePlus
K383	Ubiquitination		score1	PhosphoSitePlus
S387	Phosphorylation		score2	UniProt	17197699
S390	Phosphorylation		score3	PhosphoSitePlus UniProt	17197699
K391	Ubiquitination		score1	PhosphoSitePlus
S397	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	18088087, 17197699
S397	Phosphorylation	P51955 (NEK2)	score3	neXtProt PhosphoSitePlus	17197699
S400	Phosphorylation		score1	PhosphoSitePlus
S402	Phosphorylation		score3	neXtProt PhosphoSitePlus UniProt	17197699
S402	Phosphorylation	P51955 (NEK2)	score3	neXtProt PhosphoSitePlus	17197699
T405	Phosphorylation		score1	PhosphoSitePlus
S406	Phosphorylation		score3	neXtProt PhosphoSitePlus UniProt	21076410
S406	Phosphorylation	Q13188 (STK3)	score3	neXtProt PhosphoSitePlus	21076410
K407	Ubiquitination		score1	PhosphoSitePlus
S408	Phosphorylation		score1	PhosphoSitePlus
S428	Phosphorylation		score3	neXtProt PhosphoSitePlus UniProt	17197699
S428	Phosphorylation	P51955 (NEK2)	score3	neXtProt PhosphoSitePlus	17197699
K432	Ubiquitination		score1	PhosphoSitePlus
K437	Acetylation		score1	PhosphoSitePlus
K437	Ubiquitination		score1	PhosphoSitePlus
S438	Phosphorylation		score3	neXtProt PhosphoSitePlus Signor UniProt	21076410
S438	Phosphorylation	Q13188 (STK3)	score3	neXtProt PhosphoSitePlus Signor	21076410

Site	PTM Type	Score	Source	PMID
T170	Phosphorylation	score0	HPRD	18691976
S184	Phosphorylation	score0	HPRD	18691976
S296	Phosphorylation	score0	HPRD	18691976
S299	Phosphorylation	score0	HPRD	18691976
S300	Phosphorylation	score0	HPRD	18691976
S397	Phosphorylation	score0	HPRD	18088087

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S365	Phosphorylation		score1	PhosphoSitePlus
	S368	Phosphorylation		score1	PhosphoSitePlus

P51955 (NEK2) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O14777 (NDC80)	S165	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor	12386167, 18297113, 21832156
O15360 (FANCA)	T351	score2	PhosphoSitePlus	23806870
P06748 (NPM1)	S70	score2	PhosphoSitePlus	23851489
P06748 (NPM1)	S88	score2	PhosphoSitePlus	23851489
P36873 (PPP1CC)	T307	score3	neXtProt phospho.ELM PhosphoSitePlus Signor	10880350
P36873 (PPP1CC)	T318	score3	neXtProt phospho.ELM PhosphoSitePlus Signor	10880350
P51955 (NEK2)	T170	score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
P51955 (NEK2)	S171	score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
P51955 (NEK2)	T175	score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
P51955 (NEK2)	T179	score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
P51955 (NEK2)	S241	score3	neXtProt PhosphoSitePlus Signor UniProt	17197699
P51955 (NEK2)	S356	score3	neXtProt PhosphoSitePlus	17197699
P51955 (NEK2)	S397	score3	neXtProt PhosphoSitePlus	17197699
P51955 (NEK2)	S402	score3	neXtProt PhosphoSitePlus	17197699
P51955 (NEK2)	S428	score3	neXtProt PhosphoSitePlus	17197699
Q5FBB7 (SGO1)	S14	score3	neXtProt PhosphoSitePlus Signor	17621308
Q5FBB7 (SGO1)	S507	score3	neXtProt PhosphoSitePlus Signor	17621308
Q8N137 (CNTROB)	T35	score2	PhosphoSitePlus	23291182
Q8N137 (CNTROB)	S36	score2	PhosphoSitePlus	23291182
Q8N137 (CNTROB)	S41	score2	PhosphoSitePlus	23291182
Q8N137 (CNTROB)	S45	score2	PhosphoSitePlus	23291182
Q9BV73 (CEP250)	S2392	score1	Signor	24695856
Q9BV73 (CEP250)	S2394	score1	Signor	24695856
Q9BV73 (CEP250)	S2417	score2	PhosphoSitePlus	21076410
Q9BV73 (CEP250)	S2421	score2	PhosphoSitePlus	21076410
Q9H2D6-5 (TRIOBP)	T221	score2	PhosphoSitePlus	24692559

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
K156	N156	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T179	I179	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S296	L296	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S299	F299	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K309	*	Biomuta	DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K353	M353	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S402	G402	Biomuta	DOID:263 / kidney cancer [ cosmic, icgc ]
T405	I405	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S408	P408	Biomuta	DOID:363 / uterine cancer [ icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P51955 (NEK2)

Protein Information

Interactive Sequence View

P51955 (NEK2) as Substrate

P51955 (NEK2) as PTM Enzyme

PTM sites affected in variants