Protein Information

Cytoscape View


UniProt AC / UniProt ID P51955 / NEK2_HUMAN
Protein Name Serine/threonine-protein kinase Nek2
Gene Name Name: NEK2
Synonyms:NEK2A,NLK1;
Organism Homo sapiens (Human)

PRO ID PR:P51955
DAG View
PRO Name serine/threonine-protein kinase Nek2 (human)
Definition A serine/threonine-protein kinase Nek2 that is encoded in the genome of human.
Short Label hNEK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51955 (NEK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K37 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
T170 Phosphorylation P51955 (NEK2) neXtProt   PhosphoSitePlus   Signor   UniProt 17197699
S171 Phosphorylation P51955 (NEK2) neXtProt   PhosphoSitePlus   Signor   UniProt 23186163, 17197699
K174 Ubiquitination PhosphoSitePlus
T175 Phosphorylation P51955 (NEK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20936789, 17197699
T179 Phosphorylation P51955 (NEK2) neXtProt   PhosphoSitePlus   Signor   UniProt 17197699
S184 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163
S192 Phosphorylation RLIMS-P 31870452
K227 Ubiquitination PhosphoSitePlus
S241 Phosphorylation P51955 (NEK2) neXtProt   PhosphoSitePlus   Signor   UniProt 17197699
S261 Phosphorylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S300 Phosphorylation PhosphoSitePlus   UniProt 23186163
S304 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
S356 Phosphorylation P51955 (NEK2) , Q13188 (STK3) neXtProt   PhosphoSitePlus   UniProt 21076410, 17197699
K359 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S365 Phosphorylation Q13188 (STK3) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21076410, 22067460
S378 Phosphorylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
S387 Phosphorylation UniProt 17197699
S390 Phosphorylation PhosphoSitePlus   UniProt 17197699
K391 Ubiquitination PhosphoSitePlus
S397 Phosphorylation P51955 (NEK2) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18088087, 17197699
S400 Phosphorylation PhosphoSitePlus
S402 Phosphorylation P51955 (NEK2) neXtProt   PhosphoSitePlus   UniProt 17197699
T405 Phosphorylation PhosphoSitePlus
S406 Phosphorylation Q13188 (STK3) neXtProt   PhosphoSitePlus   UniProt 21076410
K407 Ubiquitination PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
S428 Phosphorylation P51955 (NEK2) neXtProt   PhosphoSitePlus   UniProt 17197699
K432 Ubiquitination PhosphoSitePlus
K437 Acetylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
S438 Phosphorylation Q13188 (STK3) neXtProt   PhosphoSitePlus   Signor   UniProt 21076410
Site PTM Type PTM Enzyme Score Source PMID
T170 Phosphorylation HPRD 18691976
S184 Phosphorylation HPRD 18691976
S296 Phosphorylation HPRD 18691976
S299 Phosphorylation HPRD 18691976
S300 Phosphorylation HPRD 18691976
S397 Phosphorylation HPRD 18088087
Site PTM Type PTM Enzyme Score Source PMID
S365 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus


P51955 (NEK2) as PTM Enzyme



Substrate Site Score Source PMID
O14777 (NDC80) S165 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12386167, 18297113, 21832156
O15360 (FANCA) T351 PhosphoSitePlus 23806870
P06748 (NPM1) S70 PhosphoSitePlus 23851489
P06748 (NPM1) S88 PhosphoSitePlus 23851489
P36873 (PPP1CC) T307 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10880350
P36873 (PPP1CC) T318 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10880350
P51955 (NEK2) T170 neXtProt   PhosphoSitePlus   Signor   UniProt 17197699
P51955 (NEK2) S171 neXtProt   PhosphoSitePlus   Signor   UniProt 17197699
P51955 (NEK2) T175 neXtProt   PhosphoSitePlus   Signor   UniProt 17197699
P51955 (NEK2) T179 neXtProt   PhosphoSitePlus   Signor   UniProt 17197699
P51955 (NEK2) S241 neXtProt   PhosphoSitePlus   Signor   UniProt 17197699
P51955 (NEK2) S356 neXtProt   PhosphoSitePlus 17197699
P51955 (NEK2) S397 neXtProt   PhosphoSitePlus 17197699
P51955 (NEK2) S402 neXtProt   PhosphoSitePlus 17197699
P51955 (NEK2) S428 neXtProt   PhosphoSitePlus 17197699
Q5FBB7 (SGO1) S14 neXtProt   PhosphoSitePlus   Signor 17621308
Q5FBB7 (SGO1) S507 neXtProt   PhosphoSitePlus   Signor 17621308
Q8N137 (CNTROB) T35 PhosphoSitePlus 23291182
Q8N137 (CNTROB) S36 PhosphoSitePlus 23291182
Q8N137 (CNTROB) S41 PhosphoSitePlus 23291182
Q8N137 (CNTROB) S45 PhosphoSitePlus 23291182
Q9BV73 (CEP250) S2392 Signor 24695856
Q9BV73 (CEP250) S2394 Signor 24695856
Q9BV73 (CEP250) S2417 PhosphoSitePlus 21076410
Q9BV73 (CEP250) S2421 PhosphoSitePlus 21076410
Q9H2D6-5 (TRIOBP) T221 PhosphoSitePlus 24692559


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T170 M170 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
S296 L296 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ tcga ] DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S299 Y299 Biomuta DOID:3571 / liver cancer [ icgc ]
S299 F299 Biomuta DOID:1324 / lung cancer [ cosmic ]
S402 G402 Biomuta DOID:263 / kidney cancer [ tcga ]
T405 I405 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S408 P408 Biomuta DOID:363 / uterine cancer [ tcga ]