iPTMnet Report for P51787 (KCNQ1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51787 / KCNQ1_HUMAN
Protein Name Potassium voltage-gated channel subfamily KQT member 1
Gene Name Name: KCNQ1
Synonyms:KCNA8;
Organism Homo sapiens (Human)

PRO ID PR:P51787
DAG View
PRO Name potassium voltage-gated channel subfamily KQT member 1 (human)
Definition A voltage-gated potassium channel subunit KCNQ1 that is encoded in the genome of human.
Short Label hKCNQ1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51787 (KCNQ1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation RLIMS-P 22095730
S27 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P   UniProt 22095730, 25037568, 11799244, ...31461851
S92 Phosphorylation PhosphoSitePlus   RLIMS-P 31461851
Y94 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
T404 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
K424 Sumoylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
C445 S-Nitrosylation dbSNO 19124472, 22178444
Y461 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
T470 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
T482 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
T513 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Y6H6 (KCNE3) S82 P51787 (KCNQ1) unknown eFIP 33363037
Phosphorylation Q9Y6H6 (KCNE3) S82 P51787 (KCNQ1) unknown eFIP 27626070


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S199 F199 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S409 G409 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S484 N484 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]