iPTMnet Report for P51787 (KCNQ1)
Protein Information
| UniProt AC / UniProt ID | P51787 / KCNQ1_HUMAN |
| Protein Name | Potassium voltage-gated channel subfamily KQT member 1 |
| Gene Name | Name: KCNQ1 Synonyms:KCNA8; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P51787 |
| PRO Name | potassium voltage-gated channel subfamily KQT member 1 (human) |
| Definition | A voltage-gated potassium channel subunit KCNQ1 that is encoded in the genome of human. |
| Short Label | hKCNQ1 |
| Category | organism-gene |
DAG ViewP51787 (KCNQ1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S6 | Phosphorylation | score0 | RLIMS-P | 22095730 | ||
| S27 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 22095730, 25037568, 11799244, ... | ||
| S27 | Phosphorylation | P17612 (PRKACA) | score2 | PhosphoSitePlus | 22095730 | |
| S92 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31461851 | ||
| Y94 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S95 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T96 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S199 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T404 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S409 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K424 | Sumoylation | score1 | PhosphoSitePlus | |||
| K424 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C445 | S-Nitrosylation | score2 | dbSNO | 19124472, 22178444 | ||
| Y461 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S464 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S468 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T470 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S475 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T482 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S484 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T513 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S577 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q9Y6H6 (KCNE3) | S82 | P51787 (KCNQ1) | unknown | eFIP | 33363037 | |
| Phosphorylation | Q9Y6H6 (KCNE3) | S82 | P51787 (KCNQ1) | unknown | eFIP | 27626070 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S199 | F199 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S409 | G409 | Biomuta | DOID:2531 / hematologic cancer [ cosmic, icgc ] | |
| S484 | N484 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] |
