iPTMnet Report for P51114 (FXR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P51114 / FXR1_HUMAN
Protein Name RNA-binding protein FXR1
Gene Name Name: FXR1
Organism Homo sapiens (Human)

PRO ID PR:P51114
DAG View
PRO Name RNA-binding protein FXR1 (human)
Definition An RNA-binding protein FXR1 that is encoded in the genome of human.
Short Label hFXR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51114 (FXR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S11 Phosphorylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
K56 Sumoylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
C157 Methylation IEDB 31844290
K179 Ubiquitination PhosphoSitePlus
R190 Methylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
C211 Methylation IEDB 31844290
K213 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
Y357 Phosphorylation PhosphoSitePlus
R365 Methylation PhosphoSitePlus
R368 Methylation PhosphoSitePlus
R376 Methylation PhosphoSitePlus
R386 Methylation PhosphoSitePlus
R388 Methylation PhosphoSitePlus
T401 Phosphorylation PhosphoSitePlus   UniProt 23186163
S406 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332
S409 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332
T411 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 20068231, ...20417602
S420 Phosphorylation Q13153 (PAK1) PhosphoSitePlus 20417602
S423 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S432 Phosphorylation PhosphoSitePlus   UniProt 23186163
S438 Phosphorylation PhosphoSitePlus
R445 Methylation PhosphoSitePlus
R453 Methylation PhosphoSitePlus
R455 Methylation PhosphoSitePlus
R459 Methylation IEDB   PhosphoSitePlus 27503676
K462 Methylation PhosphoSitePlus
S463 O-Glycosylation GlyGen 23301498, 33214551, 34725712, ...30059200, 34019948, 35083852, 28510447, 22121020, 34229054
S464 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
Y477 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
T483 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S485 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
T488 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T491 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S494 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S496 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
T500 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S506 Phosphorylation PhosphoSitePlus
T511 Phosphorylation PhosphoSitePlus
S524 Phosphorylation UniProt 19690332
S528 Phosphorylation UniProt 19690332
Y540 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332
S592 Phosphorylation PhosphoSitePlus
T597 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
T611 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
Site PTM Type PTM Enzyme Score Source PMID
T401 Phosphorylation HPRD 17081983
S403 Phosphorylation HPRD 17081983
S406 Phosphorylation HPRD 18669648, 17081983, 18452278
S409 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
T411 Phosphorylation HPRD 17081983
S413 Phosphorylation HPRD 17081983
S420 Phosphorylation HPRD 19651622, 20068231
S423 Phosphorylation HPRD 19651622, 20068231
S432 Phosphorylation HPRD 19651622
Y477 Phosphorylation HPRD 17081983
T483 Phosphorylation HPRD 18691976, 18669648, 18452278
S485 Phosphorylation HPRD 18669648, 17081983
T488 Phosphorylation HPRD 18669648, 17081983
T491 Phosphorylation HPRD 18669648, 18452278
S494 Phosphorylation HPRD 18669648, 17081983
T500 Phosphorylation HPRD 18669648
S587 Phosphorylation HPRD 19413330, 19664995
T597 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T401 Phosphorylation HPRD 17081983
S403 Phosphorylation HPRD 17081983
S406 Phosphorylation HPRD 18669648, 17081983, 18452278
S409 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
T411 Phosphorylation HPRD 17081983
S413 Phosphorylation HPRD 17081983
S420 Phosphorylation HPRD 19651622, 20068231
S423 Phosphorylation HPRD 19651622, 20068231
S432 Phosphorylation HPRD 19651622
Y477 Phosphorylation HPRD   PhosphoSitePlus 17081983
T483 Phosphorylation HPRD 18691976, 18669648, 18452278
S485 Phosphorylation HPRD 18669648, 17081983
T488 Phosphorylation HPRD 18669648, 17081983
T491 Phosphorylation HPRD 18669648, 18452278
S494 Phosphorylation HPRD 18669648, 17081983
T500 Phosphorylation HPRD 18669648
T511 Phosphorylation PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T316 Phosphorylation HPRD 17081983
S318 Phosphorylation HPRD 17081983
S321 Phosphorylation HPRD 18669648, 17081983, 18452278
S324 Phosphorylation HPRD   phospho.ELM 19651622, 18669648, 17081983, ...18452278
T326 Phosphorylation HPRD 17081983
S328 Phosphorylation HPRD 17081983
S335 Phosphorylation HPRD 19651622, 20068231
S338 Phosphorylation HPRD 19651622, 20068231
S347 Phosphorylation HPRD 19651622
Y392 Phosphorylation HPRD   PhosphoSitePlus 17081983
T398 Phosphorylation HPRD 18691976, 18669648, 18452278
S400 Phosphorylation HPRD 18669648, 17081983
T403 Phosphorylation HPRD 18669648, 17081983
T406 Phosphorylation HPRD 18669648, 18452278
S409 Phosphorylation HPRD 18669648, 17081983
T415 Phosphorylation HPRD 18669648
S421 Phosphorylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
S502 Phosphorylation HPRD 19413330, 19664995
T512 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K83 T83 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
C157 F157 Biomuta DOID:1324 / lung cancer [ cosmic ]
R190 L190 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R190 Q190 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S191 G191 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K195 N195 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K273 Q273 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K295 N295 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S321 F321 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S324 C324 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K325 I325 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S328 C328 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R365 T365 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R368 C368 Biomuta [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:1115 / sarcoma [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R376 Q376 Biomuta DOID:363 / uterine cancer [ icgc ]
R376 L376 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R376 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T398 A398 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S400 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S406 F406 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S409 C409 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S413 C413 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T426 I426 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R453 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R453 Q453 Biomuta [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R455 H455 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R455 C455 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R459 C459 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R459 H459 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S467 Y467 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T483 A483 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S485 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T511 I511 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T512 A512 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S592 C592 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T597 A597 Biomuta DOID:10534 / stomach cancer [ cosmic ]