Protein Information

Cytoscape View


UniProt AC / UniProt ID P51114 / FXR1_HUMAN
Protein Name Fragile X mental retardation syndrome-related protein 1
Gene Name Name: FXR1
Organism Homo sapiens (Human)

PRO ID PR:P51114
DAG View
PRO Name fragile X mental retardation syndrome-related protein 1 (human)
Definition A fragile X mental retardation syndrome-related protein 1 that is encoded in the genome of human.
Short Label hFXR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P51114 (FXR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S11 Phosphorylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
R190 Methylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
Y357 Phosphorylation PhosphoSitePlus
R365 Methylation PhosphoSitePlus
R368 Methylation PhosphoSitePlus
R376 Methylation PhosphoSitePlus
R386 Methylation PhosphoSitePlus
T401 Phosphorylation PhosphoSitePlus   UniProt 23186163
S406 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332
S409 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332
T411 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
S420 Phosphorylation Q13153 (PAK1) PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 20068231, ...20417602
S423 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S432 Phosphorylation PhosphoSitePlus   UniProt 23186163
S438 Phosphorylation PhosphoSitePlus
R445 Methylation PhosphoSitePlus
R453 Methylation PhosphoSitePlus
R455 Methylation PhosphoSitePlus
R459 Methylation PhosphoSitePlus
K462 Methylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
Y477 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
T483 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S485 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648
T488 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T491 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S494 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S496 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
T500 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S506 Phosphorylation PhosphoSitePlus
T511 Phosphorylation PhosphoSitePlus
Y540 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332
S592 Phosphorylation PhosphoSitePlus
T597 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
T611 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
Site PTM Type PTM Enzyme Score Source PMID
T401 Phosphorylation HPRD 17081983
S403 Phosphorylation HPRD 17081983
S406 Phosphorylation HPRD 18669648, 17081983, 18452278
S409 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
T411 Phosphorylation HPRD 17081983
S413 Phosphorylation HPRD 17081983
S420 Phosphorylation HPRD 19651622, 20068231
S423 Phosphorylation HPRD 19651622, 20068231
S432 Phosphorylation HPRD 19651622
Y477 Phosphorylation HPRD 17081983
T483 Phosphorylation HPRD 18691976, 18669648, 18452278
S485 Phosphorylation HPRD 18669648, 17081983
T488 Phosphorylation HPRD 18669648, 17081983
T491 Phosphorylation HPRD 18669648, 18452278
S494 Phosphorylation HPRD 18669648, 17081983
T500 Phosphorylation HPRD 18669648
S587 Phosphorylation HPRD 19413330, 19664995
T597 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T401 Phosphorylation HPRD 17081983
S403 Phosphorylation HPRD 17081983
S406 Phosphorylation HPRD 18669648, 17081983, 18452278
S409 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
T411 Phosphorylation HPRD 17081983
S413 Phosphorylation HPRD 17081983
S420 Phosphorylation HPRD 19651622, 20068231
S423 Phosphorylation HPRD 19651622, 20068231
S432 Phosphorylation HPRD 19651622
Y477 Phosphorylation HPRD   PhosphoSitePlus 17081983
T483 Phosphorylation HPRD 18691976, 18669648, 18452278
S485 Phosphorylation HPRD 18669648, 17081983
T488 Phosphorylation HPRD 18669648, 17081983
T491 Phosphorylation HPRD 18669648, 18452278
S494 Phosphorylation HPRD 18669648, 17081983
T500 Phosphorylation HPRD 18669648
T511 Phosphorylation PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T316 Phosphorylation HPRD 17081983
S318 Phosphorylation HPRD 17081983
S321 Phosphorylation HPRD 18669648, 17081983, 18452278
S324 Phosphorylation HPRD   phospho.ELM 19651622, 18669648, 17081983, ...18452278
T326 Phosphorylation HPRD 17081983
S328 Phosphorylation HPRD 17081983
S335 Phosphorylation HPRD 19651622, 20068231
S338 Phosphorylation HPRD 19651622, 20068231
S347 Phosphorylation HPRD 19651622
Y392 Phosphorylation HPRD   PhosphoSitePlus 17081983
T398 Phosphorylation HPRD 18691976, 18669648, 18452278
S400 Phosphorylation HPRD 18669648, 17081983
T403 Phosphorylation HPRD 18669648, 17081983
T406 Phosphorylation HPRD 18669648, 18452278
S409 Phosphorylation HPRD 18669648, 17081983
T415 Phosphorylation HPRD 18669648
S421 Phosphorylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
S502 Phosphorylation HPRD 19413330, 19664995
T512 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K57 Q57 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K83 T83 Biomuta DOID:1909 / melanoma [ cosmic ]
R190 L190 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R190 Q190 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]
S191 G191 Biomuta DOID:1324 / lung cancer [ tcga ]
K195 N195 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K273 Q273 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K325 I325 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R365 T365 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R368 C368 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1115 / sarcoma [ tcga ]
R376 * Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ]
S406 F406 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S413 C413 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R453 * Biomuta DOID:1319 / brain cancer [ icgc ]
R453 Q453 Biomuta DOID:3571 / liver cancer [ icgc ]
R455 H455 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic, tcga ]
R455 C455 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R459 C459 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:5041 / esophageal cancer [ tcga ]
R459 H459 Biomuta DOID:1324 / lung cancer [ tcga ]
S467 Y467 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
Y477 H477 Biomuta DOID:2394 / ovarian cancer [ tcga ]
S592 F592 Biomuta DOID:363 / uterine cancer [ tcga ]
S592 Y592 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T597 A597 Biomuta DOID:10534 / stomach cancer [ cosmic ]