iPTMnet Report P50552 VASP

Protein Information

UniProt AC / UniProt ID	P50552 / VASP_HUMAN
Protein Name	Vasodilator-stimulated phosphoprotein
Gene Name	Name: VASP
Organism	Homo sapiens (Human)

PRO ID	PR:P50552 DAG View
PRO Name	vasodilator-stimulated phosphoprotein (human)
Definition	A vasodilator-stimulated phosphoprotein that is encoded in the genome of human.
Short Label	hVASP
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P50552 (VASP) as Substrate

P50552

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S2 S8 Y16 Y39 T43 S46 K53 R68 K71 S134 S157 S239 T249 K252 S258 T278 K283 T284 K286 S289 S305 K312 S314 T315 T316 K321 S322 S323 S324 S325 T327 T328 T331 T335 S337 Y341 K348 K363	PTM Type Select all Acetylation Methylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme Select all P17252 (PRKCA) P17612 (PRKACA) P54646 (PRKAA2) Q13131 (PRKAA1) Q13237 (PRKG2) Q13976 (PRKG1) Q15139 (PRKD1) Q15418 (RPS6KA1) Q9BZL6 (PRKD2) Q9UM73 (ALK)	Score Select all 1 2 3 4	Source Select all HPRD PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
S2	Acetylation		score1	UniProt	19413330, 22814378, 12665801, ...22223895
S2	Phosphorylation		score1	PhosphoSitePlus
S8	Phosphorylation		score1	PhosphoSitePlus
Y16	Phosphorylation		score1	PhosphoSitePlus
Y39	Phosphorylation		score4	HPRD phospho.ELM PhosphoSitePlus RLIMS-P UniProt	18083107, 23186163, 28783324, ...19651622, 18845790, 15592455, 27711191, 20068231, 16497976
Y39	Phosphorylation	Q9UM73 (ALK)	score2	PhosphoSitePlus	18845790
T43	Phosphorylation		score1	PhosphoSitePlus
S46	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K53	Acetylation		score1	PhosphoSitePlus
R68	Methylation		score1	PhosphoSitePlus
K71	Ubiquitination		score1	PhosphoSitePlus
S134	Phosphorylation		score1	PhosphoSitePlus
S157	Phosphorylation		score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	8182057, 12576312, 18832777, ...17167837, 31831789, 21472294, 20404115, 27959381, 18195108, 27746688, 11919161, 14602552, 27711191, 22347188, 19711176, 17867432, 23743824, 22210825, 27896950, 17463178, 29401709, 32397169, 25543053, 7925440, 16283430, 11748216, 20058876, 15178555, 27898723, 22034949, 32085646, 26336132, 21451103, 20624010, 29435180, 25759389, 25056834, 20525309, 18559661, 9685341, 25913239, 25298072, 33129878, 23909451, 29653944, 21218856, 33777164, 18637808, 28278256, 23846685, 17684042, 19165715, 24856644, 16197368, 25561938, 7980622, 23850619, 25450971, 18281604, 20958117, 32331276, 24691407, 15265792, 28254816, 33634102, 14679200
S157	Phosphorylation	P17252 (PRKCA)	score2	PhosphoSitePlus	18637808
S157	Phosphorylation	P17612 (PRKACA)	score4	HPRD PhosphoSitePlus Signor	12576312, 8182057, 18195108, ...20058876, 16197368
S157	Phosphorylation	Q13976 (PRKG1)	score4	HPRD neXtProt PhosphoSitePlus Signor	12576312, 8182057, 14679200, ...20058876
S157	Phosphorylation	Q15139 (PRKD1)	score2	PhosphoSitePlus	23846685
S157	Phosphorylation	Q9BZL6 (PRKD2)	score2	PhosphoSitePlus	26336132
S239	Phosphorylation		score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	27711191, 17463178, 8182057, ...26440524, 17049286, 14602552, 28405672, 26652273, 31831789, 19798690, 32647264, 21451103, 27746688, 18022387, 29024896, 21827504, 27896950, 33634102, 21502370, 29659727, 23909451, 23186163, 24779009, 21702043, 18637808, 24963131, 28661475, 25056834, 15178555, 18079207, 22034949, 27515066, 12576312, 17913834, 29155852, 26336132, 20624010, 29435180, 26635911, 18559661, 9685341, 25913239, 15670578, 33129878, 15694326, 29653944, 21218856, 22020732, 32704001, 18445594, 22347188, 18551195, 30460698, 22942288, 17287340, 25561938, 23162660, 17100655, 18281604, 18079117, 24691407, 17684063, 20483741, 20166139, 25543053, 19825941, 14679200, 23469931
S239	Phosphorylation	P17612 (PRKACA)	score4	HPRD PhosphoSitePlus Signor	20166139, 12576312, 8182057, ...17287340
S239	Phosphorylation	Q13237 (PRKG2)	score2	neXtProt	18551195
S239	Phosphorylation	Q13976 (PRKG1)	score4	HPRD neXtProt PhosphoSitePlus Signor	12576312, 8182057, 22942288, ...17287340, 15694326, 20483741, 20166139, 14679200, 18637808
S239	Phosphorylation	Q9BZL6 (PRKD2)	score2	PhosphoSitePlus	26336132
T249	Phosphorylation		score2	HPRD PhosphoSitePlus	20068231
K252	Acetylation		score1	PhosphoSitePlus
S258	Phosphorylation		score1	PhosphoSitePlus
T278	Phosphorylation		score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	12576312, 8182057, 21451103, ...30460698, 26652273, 24691407, 27711191, 21423205, 17082196, 18637808
T278	Phosphorylation	P17612 (PRKACA)	score3	HPRD PhosphoSitePlus	8182057
T278	Phosphorylation	P54646 (PRKAA2)	score1	Signor	17082196
T278	Phosphorylation	Q13131 (PRKAA1)	score2	PhosphoSitePlus	17082196
T278	Phosphorylation	Q13976 (PRKG1)	score4	HPRD neXtProt PhosphoSitePlus Signor	12576312, 8182057, 18637808
T278	Phosphorylation	Q15418 (RPS6KA1)	score3	PhosphoSitePlus Signor	21423205
K283	Acetylation		score2	PhosphoSitePlus UniProt	19608861
T284	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	23186163, 20068231
K286	Sumoylation		score1	PhosphoSitePlus
S289	Phosphorylation		score1	PhosphoSitePlus
S305	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K312	Ubiquitination		score1	PhosphoSitePlus
S314	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
T315	Phosphorylation		score1	phospho.ELM	18669648
T316	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	17322306, 18669648, 20058876, ...20068231
K321	Methylation		score1	PhosphoSitePlus
K321	Ubiquitination		score1	PhosphoSitePlus
S322	Phosphorylation		score4	HPRD phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	26336132, 23846685, 18669648, ...27711191, 21945940
S322	Phosphorylation	P54646 (PRKAA2)	score1	Signor	21945940
S322	Phosphorylation	Q15139 (PRKD1)	score2	PhosphoSitePlus	23846685
S322	Phosphorylation	Q9BZL6 (PRKD2)	score2	PhosphoSitePlus	26336132
S323	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	18669648, 20230923
S324	Phosphorylation		score2	HPRD PhosphoSitePlus	18669648, 20230923
S325	Phosphorylation		score2	HPRD PhosphoSitePlus	20230923
T327	Phosphorylation		score2	HPRD PhosphoSitePlus	18669648
T328	Phosphorylation		score1	PhosphoSitePlus
T331	Phosphorylation		score1	PhosphoSitePlus
T335	Phosphorylation		score1	PhosphoSitePlus
S337	Phosphorylation		score1	PhosphoSitePlus
Y341	Phosphorylation		score1	PhosphoSitePlus
K348	Ubiquitination		score1	PhosphoSitePlus
K363	Ubiquitination		score1	PhosphoSitePlus

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all P50552 (VASP)	Site Select all By amino acid All Serine By position S157	Interactant Select all P00519 (ABL1)	Association type Select all decreased_association	Source Select all eFIP	PMID
	Phosphorylation	P50552 (VASP)	S157	P00519 (ABL1)	decreased_association	eFIP	25450971

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position Y16 R68 S157 K286 S305 K312 K321 S325 T331 T335	Variant Select all A331 A335 C16 C305 E321 F157 L325 N286 P68 T312 Y157	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ icgc ]
Y16	C16	Biomuta	DOID:3571 / liver cancer [ cosmic ]
R68	P68	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S157	F157	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S157	Y157	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
K286	N286	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S305	C305	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K312	T312	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K321	E321	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S325	L325	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
T331	A331	Biomuta	DOID:9256 / colorectal cancer [ icgc ]
T335	A335	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P50552 (VASP)

Protein Information

Interactive Sequence View

P50552 (VASP) as Substrate

PTM-dependent PPI

PTM sites affected in variants