Protein Information

Cytoscape View


UniProt AC / UniProt ID P50552 / VASP_HUMAN
Protein Name Vasodilator-stimulated phosphoprotein
Gene Name Name: VASP
Organism Homo sapiens (Human)

PRO ID PR:P50552
DAG View
PRO Name vasodilator-stimulated phosphoprotein (human)
Definition A vasodilator-stimulated phosphoprotein that is encoded in the genome of human.
Short Label hVASP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P50552 (VASP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378, 12665801, ...22223895
S2 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
Y16 Phosphorylation PhosphoSitePlus
Y39 Phosphorylation Q9UM73 (ALK) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18083107, 23186163, 19651622, ...18845790, 15592455, 27711191, 20068231, 16497976
T43 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus   UniProt 23186163
K53 Acetylation PhosphoSitePlus
R68 Methylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S157 Phosphorylation P17252 (PRKCA) , P17612 (PRKACA) , Q15139 (PRKD1) , Q13976 (PRKG1) , Q9BZL6 (PRKD2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8182057, 18832777, 17167837, ...18637808, 21472294, 20404115, 27959381, 18195108, 27746688, 11919161, 14602552, 27711191, 22347188, 27896950, 23909451, 22210825, 17463178, 25759389, 19165715, 25543053, 7925440, 16283430, 11748216, 20058876, 27898723, 22034949, 12576312, 26336132, 21451103, 20624010, 29435180, 19711176, 25056834, 20525309, 18559661, 9685341, 25913239, 25298072, 7980622, 11384196, 23846685, 17684042, 31162891, 24856644, 16197368, 25561938, 19081821, 23850619, 25450971, 18281604, 20958117, 24691407, 15265792, 28254816, 14679200
S239 Phosphorylation Q13976 (PRKG1) , Q13237 (PRKG2) , P17612 (PRKACA) , Q9BZL6 (PRKD2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27711191, 8182057, 17463178, ...17049286, 14602552, 28405672, 26652273, 18637808, 19798690, 27959381, 18195108, 27746688, 18022387, 29024896, 21827504, 18349137, 27896950, 21502370, 29659727, 23909451, 23186163, 24779009, 21702043, 31281522, 24963131, 28661475, 18445594, 22034949, 27515066, 12576312, 17913834, 29155852, 26336132, 20624010, 29435180, 25056834, 18559661, 9685341, 25913239, 15670578, 15694326, 21398595, 23469931, 21451103, 22020732, 17684063, 22347188, 18551195, 30460698, 22942288, 17287340, 25561938, 23162660, 17100655, 18281604, 18079117, 24691407, 20483741, 20166139, 25543053, 19825941, 14679200
T249 Phosphorylation HPRD   PhosphoSitePlus 20068231
K252 Acetylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
T278 Phosphorylation Q15418 (RPS6KA1) , P54646 (PRKAA2) , P17612 (PRKACA) , Q13131 (PRKAA1) , Q13976 (PRKG1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12576312, 8182057, 21451103, ...30460698, 26652273, 27959381, 18195108, 24691407, 27711191, 21423205, 17082196, 18637808
K283 Acetylation PhosphoSitePlus   UniProt 19608861
T284 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K286 Sumoylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus   UniProt 23186163
K312 Ubiquitination PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus   UniProt 23186163
T315 Phosphorylation phospho.ELM 18669648
T316 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17322306, 18669648, 20058876, ...20068231
K321 Methylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
S322 Phosphorylation P54646 (PRKAA2) , Q15139 (PRKD1) , Q9BZL6 (PRKD2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26336132, 23846685, 18669648, ...27711191, 21945940
S323 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20230923
S324 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20230923
S325 Phosphorylation HPRD   PhosphoSitePlus 20230923
T327 Phosphorylation HPRD   PhosphoSitePlus 18669648
T328 Phosphorylation PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
Y341 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P50552 (VASP) S157 P00519 (ABL1) decreased_association eFIP 25450971


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y16 C16 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R68 P68 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K286 N286 Biomuta DOID:363 / uterine cancer [ tcga ]
K312 T312 Biomuta DOID:363 / uterine cancer [ tcga ]
K321 N321 Biomuta DOID:3571 / liver cancer [ icgc ]
S325 L325 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T331 A331 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T335 A335 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
Y341 C341 Biomuta DOID:9256 / colorectal cancer [ tcga ]