iPTMnet Report for P49810 (PSEN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49810 / PSN2_HUMAN
Protein Name Presenilin-2
Gene Name Name: PSEN2
Synonyms:AD4,PS2,PSNL2,STM2;
Organism Homo sapiens (Human)

PRO ID PR:P49810
DAG View
PRO Name presenilin-2 (human)
Definition A presenilin-2 that is encoded in the genome of human.
Short Label hPSEN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49810 (PSEN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus 8972483
S9 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus 8972483
S19 Phosphorylation phospho.ELM   PhosphoSitePlus 8972483
S22 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S25 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T27 Phosphorylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
Y294 Phosphorylation PhosphoSitePlus
K306 Acetylation PhosphoSitePlus
S327 Phosphorylation P48730 (CSNK1D) phospho.ELM   PhosphoSitePlus 9990034, 9558331
S330 Phosphorylation P48730 (CSNK1D) , P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus 9990034, 9558331
S335 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus 9558331
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation P68400 (CSNK2A1) , P48730 (CSNK1D) , P48729 (CSNK1A1) HPRD 8972483
S9 Phosphorylation P48730 (CSNK1D) , P68400 (CSNK2A1) , P48729 (CSNK1A1) HPRD 8972483
S19 Phosphorylation P48729 (CSNK1A1) , P48730 (CSNK1D) , P68400 (CSNK2A1) HPRD 8972483, 20068231
S22 Phosphorylation HPRD 19413330, 19651622, 20068231
S25 Phosphorylation HPRD 19413330, 18578522, 18767875, ...19651622, 18669648, 19415658, 20068231
T27 Phosphorylation HPRD 18578522, 20068231
S327 Phosphorylation P48730 (CSNK1D) HPRD 9990034, 9558331
S330 Phosphorylation P48730 (CSNK1D) , P68400 (CSNK2A1) HPRD 9990034, 9558331
S335 Phosphorylation P68400 (CSNK2A1) , P48730 (CSNK1D) HPRD 9558331
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation P48729 (CSNK1A1) , P48730 (CSNK1D) , P68400 (CSNK2A1) HPRD 8972483
S9 Phosphorylation P68400 (CSNK2A1) , P48729 (CSNK1A1) , P48730 (CSNK1D) HPRD 8972483
S19 Phosphorylation P68400 (CSNK2A1) , P48730 (CSNK1D) , P48729 (CSNK1A1) HPRD 8972483, 20068231
S22 Phosphorylation HPRD 19413330, 19651622, 20068231
S25 Phosphorylation HPRD 19413330, 18578522, 18767875, ...19651622, 18669648, 19415658, 20068231
T27 Phosphorylation HPRD 18578522, 20068231
S329 Phosphorylation P48730 (CSNK1D) , P68400 (CSNK2A1) HPRD 9990034, 9558331
S334 Phosphorylation P68400 (CSNK2A1) , P48730 (CSNK1D) HPRD 9558331


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 N9 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S22 L22 Biomuta DOID:363 / uterine cancer [ cosmic ]
T27 M27 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S334 L334 Biomuta DOID:4159 / skin cancer [ cosmic ]