iPTMnet Report for P49810 (PSEN2)
Protein Information
| UniProt AC / UniProt ID | P49810 / PSN2_HUMAN |
| Protein Name | Presenilin-2 |
| Gene Name | Name: PSEN2 Synonyms:AD4,PS2,PSNL2,STM2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P49810 |
| PRO Name | presenilin-2 (human) |
| Definition | A presenilin-2 that is encoded in the genome of human. |
| Short Label | hPSEN2 |
| Category | organism-gene |
DAG ViewP49810 (PSEN2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S7 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 8972483 | ||
| S7 | Phosphorylation | P68400 (CSNK2A1) | score2 | PhosphoSitePlus | 8972483 | |
| S9 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 8972483 | ||
| S9 | Phosphorylation | P68400 (CSNK2A1) | score2 | PhosphoSitePlus | 8972483 | |
| S19 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 8972483 | ||
| S22 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 20068231 | ||
| S25 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231 | ||
| T27 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S49 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K115 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y294 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K306 | Acetylation | score1 | PhosphoSitePlus | |||
| S327 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus | 9990034, 9558331 | ||
| S327 | Phosphorylation | P48730 (CSNK1D) | score2 | PhosphoSitePlus | 9558331 | |
| S330 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus | 9990034, 9558331 | ||
| S330 | Phosphorylation | P48730 (CSNK1D) | score2 | PhosphoSitePlus | 9558331 | |
| S330 | Phosphorylation | P68400 (CSNK2A1) | score2 | PhosphoSitePlus | 9558331 | |
| S335 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 9558331 | ||
| S335 | Phosphorylation | P68400 (CSNK2A1) | score2 | PhosphoSitePlus | 9558331 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S7 | Phosphorylation | score1 | HPRD | 8972483 | ||
| S7 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8972483 | |
| S7 | Phosphorylation | P48730 (CSNK1D) | score1 | HPRD | 8972483 | |
| S7 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 8972483 | |
| S9 | Phosphorylation | score1 | HPRD | 8972483 | ||
| S9 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8972483 | |
| S9 | Phosphorylation | P48730 (CSNK1D) | score1 | HPRD | 8972483 | |
| S9 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 8972483 | |
| S19 | Phosphorylation | score2 | HPRD | 8972483, 20068231 | ||
| S19 | Phosphorylation | P48729 (CSNK1A1) | score2 | HPRD | 8972483, 20068231 | |
| S19 | Phosphorylation | P48730 (CSNK1D) | score2 | HPRD | 8972483, 20068231 | |
| S19 | Phosphorylation | P68400 (CSNK2A1) | score2 | HPRD | 8972483, 20068231 | |
| S22 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 20068231 | ||
| S25 | Phosphorylation | score0 | HPRD | 19413330, 18578522, 18767875, ... | ||
| T27 | Phosphorylation | score0 | HPRD | 18578522, 20068231 | ||
| S327 | Phosphorylation | score2 | HPRD | 9990034, 9558331 | ||
| S327 | Phosphorylation | P48730 (CSNK1D) | score2 | HPRD | 9990034, 9558331 | |
| S330 | Phosphorylation | score2 | HPRD | 9990034, 9558331 | ||
| S330 | Phosphorylation | P48730 (CSNK1D) | score2 | HPRD | 9990034, 9558331 | |
| S330 | Phosphorylation | P68400 (CSNK2A1) | score2 | HPRD | 9990034, 9558331 | |
| S335 | Phosphorylation | score1 | HPRD | 9558331 | ||
| S335 | Phosphorylation | P48730 (CSNK1D) | score1 | HPRD | 9558331 | |
| S335 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 9558331 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S7 | Phosphorylation | score1 | HPRD | 8972483 | ||
| S7 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8972483 | |
| S7 | Phosphorylation | P48730 (CSNK1D) | score1 | HPRD | 8972483 | |
| S7 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 8972483 | |
| S9 | Phosphorylation | score1 | HPRD | 8972483 | ||
| S9 | Phosphorylation | P48729 (CSNK1A1) | score1 | HPRD | 8972483 | |
| S9 | Phosphorylation | P48730 (CSNK1D) | score1 | HPRD | 8972483 | |
| S9 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 8972483 | |
| S19 | Phosphorylation | score2 | HPRD | 8972483, 20068231 | ||
| S19 | Phosphorylation | P48729 (CSNK1A1) | score2 | HPRD | 8972483, 20068231 | |
| S19 | Phosphorylation | P48730 (CSNK1D) | score2 | HPRD | 8972483, 20068231 | |
| S19 | Phosphorylation | P68400 (CSNK2A1) | score2 | HPRD | 8972483, 20068231 | |
| S22 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 20068231 | ||
| S25 | Phosphorylation | score0 | HPRD | 19413330, 18578522, 18767875, ... | ||
| T27 | Phosphorylation | score0 | HPRD | 18578522, 20068231 | ||
| S329 | Phosphorylation | score2 | HPRD | 9990034, 9558331 | ||
| S329 | Phosphorylation | P48730 (CSNK1D) | score2 | HPRD | 9990034, 9558331 | |
| S329 | Phosphorylation | P68400 (CSNK2A1) | score2 | HPRD | 9990034, 9558331 | |
| S334 | Phosphorylation | score1 | HPRD | 9558331 | ||
| S334 | Phosphorylation | P48730 (CSNK1D) | score1 | HPRD | 9558331 | |
| S334 | Phosphorylation | P68400 (CSNK2A1) | score1 | HPRD | 9558331 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S9 | N9 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S22 | L22 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| T27 | M27 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S334 | L334 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
