iPTMnet Report for P49761 (CLK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49761 / CLK3_HUMAN
Protein Name Dual specificity protein kinase CLK3
Gene Name Name: CLK3
Organism Homo sapiens (Human)

PRO ID PR:P49761
DAG View
PRO Name dual specificity protein kinase CLK3 (human)
Definition A dual specificity protein kinase CLK3 that is encoded in the genome of human.
Short Label hCLK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49761 (CLK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y155 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S157 Phosphorylation O14757 (CHEK1) phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17192257, 18669648, ...21851590, 24275569, 19690332
Y163 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
Y174 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus   UniProt 23186163
S199 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S215 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T217 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y218 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S224 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
S226 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
Y232 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163
K288 Ubiquitination PhosphoSitePlus
T314 Phosphorylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
K328 Sumoylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y7 Phosphorylation HPRD 18691976, 18669648, 17081983, ...20068231, 18452278
S9 Phosphorylation HPRD 18691976, 18767875, 19664995, ...18452278, 19651622, 18669648
S25 Phosphorylation HPRD 18691976
Y26 Phosphorylation HPRD 20068231
S27 Phosphorylation HPRD 18691976, 20068231
S49 Phosphorylation HPRD 17081983, 20068231
S51 Phosphorylation HPRD 17081983, 20068231
S67 Phosphorylation HPRD 18691976, 18669648, 20068231
T69 Phosphorylation HPRD 18669648
Y70 Phosphorylation HPRD 18669648
S76 Phosphorylation HPRD 17322306, 18691976, 18669648, ...20068231, 18452278
S78 Phosphorylation HPRD 18691976, 18669648, 17081983, ...20068231, 18452278
S132 Phosphorylation HPRD 19651622, 20068231
S133 Phosphorylation HPRD 19651622, 20068231
S135 Phosphorylation HPRD 19651622, 18691976, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y7 C7 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S9 F9 Biomuta DOID:4159 / skin cancer [ cosmic ]
S25 F25 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y26 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S49 P49 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S67 G67 Biomuta DOID:3571 / liver cancer [ cosmic ]
S78 Y78 Biomuta DOID:10534 / stomach cancer [ cosmic ]