iPTMnet Report for P49407 (ARRB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P49407 / ARRB1_HUMAN
Protein Name Beta-arrestin-1
Gene Name Name: ARRB1
Synonyms:ARR1;
Organism Homo sapiens (Human)

PRO ID PR:P49407
DAG View
PRO Name beta-arrestin-1 (human)
Definition A beta-arrestin-1 that is encoded in the genome of human.
Short Label hARRB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49407 (ARRB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K17 Acetylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 17456469, 17456551
Y54 Phosphorylation P12931 (SRC) phospho.ELM   Signor 17456469, 17456551
Y63 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
S412 Phosphorylation IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 19661922, 19153083, ...15456867, 9388255, 10347142, 24275569, 12509508, 23186163, 20068231
S412 Phosphorylation P27361 (MAPK3) neXtProt   PhosphoSitePlus   Signor 15456867, 19153083, 10347142
S412 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 15456867, 19153083, 10347142
S412 Phosphorylation P34947 (GRK5) neXtProt 19661922
Site PTM Type PTM Enzyme Score Source PMID
T410 Phosphorylation HPRD 20068231
S412 Phosphorylation HPRD 17322306, 18767875, 19413330, ...20068231, 19651622
S412 Phosphorylation P27361 (MAPK3) HPRD 17322306, 18767875, 19413330, ...20068231, 19651622
S412 Phosphorylation P28482 (MAPK1) HPRD 17322306, 18767875, 19413330, ...20068231, 19651622
Site PTM Type PTM Enzyme Score Source PMID
T342 Phosphorylation PhosphoSitePlus
T402 Phosphorylation HPRD 20068231
S404 Phosphorylation HPRD 17322306, 18767875, 19413330, ...20068231, 19651622
S404 Phosphorylation P27361 (MAPK3) HPRD 17322306, 18767875, 19413330, ...20068231, 19651622
S404 Phosphorylation P28482 (MAPK1) HPRD 17322306, 18767875, 19413330, ...20068231, 19651622


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046398 (hARRB1/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y63 H63 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y63 C63 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S86 L86 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y173 H173 Biomuta DOID:3571 / liver cancer [ cosmic ]