Protein Information

Cytoscape View

UniProt AC / UniProt ID P49407 / ARRB1_HUMAN
Protein Name Beta-arrestin-1
Gene Name Name: ARRB1
Organism Homo sapiens (Human)

PRO ID PR:P49407
DAG View
PRO Name beta-arrestin-1 (human)
Definition A beta-arrestin-1 that is encoded in the genome of human.
Short Label hARRB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P49407 (ARRB1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K17 Acetylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 17456469, 17456551
Y63 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
S412 Phosphorylation P27361 (MAPK3) , P34947 (GRK5) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 19661922, 19153083, ...15456867, 9388255, 10347142, 24275569, 12509508, 23186163, 15520010, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T410 Phosphorylation HPRD 20068231
S412 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 17322306, 18767875, 19413330, ...20068231, 19651622
Site PTM Type PTM Enzyme Score Source PMID
T342 Phosphorylation PhosphoSitePlus
T402 Phosphorylation HPRD 20068231
S404 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) HPRD 17322306, 18767875, 19413330, ...20068231, 19651622


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046398 (hARRB1/UbiqLys+) ub PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y47 * Biomuta DOID:5041 / esophageal cancer [ tcga ]
S86 L86 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y173 H173 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]