iPTMnet Report for P49354 (FNTA)
Protein Information
| UniProt AC / UniProt ID | P49354 / FNTA_HUMAN |
| Protein Name | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| Gene Name | Name: FNTA |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P49354 |
| PRO Name | protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (human) |
| Definition | A protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha that is encoded in the genome of human. |
| Short Label | hFNTA |
| Category | organism-gene |
P49354 (FNTA) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| A2 | Acetylation | score1 | UniProt | 19413330 | ||
| S49 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S60 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y92 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S93 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K142 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K198 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K228 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T247 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T248 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y250 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R253 | Methylation | score1 | PhosphoSitePlus | |||
| R287 | Methylation | score1 | PhosphoSitePlus | |||
| K336 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K346 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T350 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y358 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K366 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T369 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S373 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
| T375 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| A2 | S2 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| R253 | H253 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
| R253 | C253 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| R287 | C287 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] | |
| Y358 | * | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T369 | S369 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| T369 | I369 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] |
DAG View